Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2007-5-1
pubmed:abstractText
To explore altered platelet function in recurrent coronary event risk among diabetic postinfarction patients, we investigated a function-altering genetic polymorphism (T145M) in the von Willebrand factor binding region of the platelet glycoprotein Ibalpha (GPIbalpha) subunit. The study comprised diabetic and nondiabetic patients of the Thrombogenic Factors and Recurrent Coronary Events postinfarction study. Cox proportional hazards multivariable modeling, adjusted for significant clinical covariates, was performed using the polymorphism and metabolic, inflammatory, and thrombogenic blood markers. Nondiabetic patients demonstrated risk for elevated lipoprotein-associated phospholipase A(2) (Lp-PLA(2)). In contrast, diabetic patients demonstrated significant and independent risk for the M allele of the T145M polymorphism (MT plus MM versus TT, hazard ratio [HR] 3.73, 95% CI 1.90-7.33, P < 0.001), hypertriglyceridemia (2.91, 1.52-5.56, P = 0.001), and elevated Lp-PLA(2) (2.78, 1.45-5.35, P = 0.002). Joint risk (one, two, or three risk factors) expressed as relative outcome rates (compared with no risk factors) were 2.4, 4.0, and 8.2, respectively. We conclude that the M allele of the T145M polymorphism of the GPIbalpha subunit predicts risk for recurrent coronary events in diabetic postinfarction patients, but not in nondiabetic postinfarction patients, supportive of an important role for platelet hyperactivation in diabetic coronary heart disease.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1939-327X
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
56
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1429-35
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:17303802-Amino Acid Substitution, pubmed-meshheading:17303802-Biological Markers, pubmed-meshheading:17303802-Cholesterol, pubmed-meshheading:17303802-Diabetic Angiopathies, pubmed-meshheading:17303802-Female, pubmed-meshheading:17303802-Genotype, pubmed-meshheading:17303802-Humans, pubmed-meshheading:17303802-Hypertriglyceridemia, pubmed-meshheading:17303802-Lipoproteins, pubmed-meshheading:17303802-Male, pubmed-meshheading:17303802-Myocardial Infarction, pubmed-meshheading:17303802-Phospholipases A, pubmed-meshheading:17303802-Phospholipases A2, pubmed-meshheading:17303802-Platelet Glycoprotein GPIb-IX Complex, pubmed-meshheading:17303802-Polymorphism, Genetic, pubmed-meshheading:17303802-Proportional Hazards Models, pubmed-meshheading:17303802-Recurrence, pubmed-meshheading:17303802-Reproducibility of Results, pubmed-meshheading:17303802-Risk Factors
pubmed:year
2007
pubmed:articleTitle
Glycoprotein Ibalpha polymorphism T145M, elevated lipoprotein-associated phospholipase A2, and hypertriglyceridemia predict risk for recurrent coronary events in diabetic postinfarction patients.
pubmed:affiliation
Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA. james_corsetti@urmc.rochester.edu
pubmed:publicationType
Journal Article, Multicenter Study, Research Support, N.I.H., Extramural