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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2007-3-19
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pubmed:abstractText |
Rheumatoid arthritis and its animal model, collagen-induced arthritis, are known as a T and B cell dependent disease. To analyze the role of B cells in arthritis, we generated B cell deficient (microMT) mice carrying HLA-DQ8 as transgene, Abetao.DQ8.micromt mice. HLA-DQ8 transgenic mice (Abetao.DQ8) are susceptible to collagen induced arthritis, an animal model for inflammatory arthritis. Deletion of IgM gene led to the absence of B cells while T cells were comparable to Abetao.DQ8 mice. Arthritis and autoantibodies was completely abrogated in B cell deficient DQ8 mice. T cell response and proinflammatory cytokine production in response to type II collagen and its derived peptides in vitro was significantly decreased despite an increased number of Mac-1 positive cells in DQ8.micromt mice compared to DQ8 mice suggesting B cells could be important for antigen presentation as well. In vitro substitution of B cells from wild type mice restored the response in DQ8.micromt mice. B cells could also present CII-derived peptides to antigen-specific DQ8-restricted hybridomas reinforcing the role of B cells in presentation of antigens to T cells. The data suggest that B cells can be involved in pathogenesis of arthritis by producing autoantibodies and antigen presentation.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17303243-10072558,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/17303243-9780157
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0161-5890
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
44
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2988-96
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pubmed:dateRevised |
2011-6-15
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pubmed:meshHeading |
pubmed-meshheading:17303243-Animals,
pubmed-meshheading:17303243-Antibody Formation,
pubmed-meshheading:17303243-Antigen Presentation,
pubmed-meshheading:17303243-Arthritis, Experimental,
pubmed-meshheading:17303243-Arthritis, Rheumatoid,
pubmed-meshheading:17303243-Autoimmunity,
pubmed-meshheading:17303243-B-Lymphocytes,
pubmed-meshheading:17303243-Genes, MHC Class II,
pubmed-meshheading:17303243-HLA-DQ Antigens,
pubmed-meshheading:17303243-Mice,
pubmed-meshheading:17303243-Mice, Transgenic,
pubmed-meshheading:17303243-Transgenes
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pubmed:year |
2007
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pubmed:articleTitle |
B cells are important as antigen presenting cells for induction of MHC-restricted arthritis in transgenic mice.
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pubmed:affiliation |
Department of Immunology, Mayo Clinic, 200 Ist Street SW, Rochester, MN 55905, USA. taneja.veena@mayo.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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