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rdf:type |
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|
lifeskim:mentions |
|
|
pubmed:issue |
32
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pubmed:dateCreated |
2007-7-12
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pubmed:abstractText |
CDX2 is a Drosophila caudal-related homeobox transcription factor that is important for the establishment and maintenance of intestinal epithelial cells. We have reported that CDX2 promotes tumorigenicity in a subset of human colorectal cancer cell lines. Here, we present evidence that CDX2 negatively regulates the well-documented growth inhibitor insulin-like growth factor binding protein-3 (IGFBP-3). Specifically, CDX2 binds to the IGFBP-3 gene promoter and can repress IGFBP-3 transcription, protein expression and secretion. Furthermore, inhibition of IGFBP-3 partially rescues the decreased anchorage-independent growth phenotype observed in CDX2 knockout cells. These data demonstrate for the first time that (1) CDX2 can function as a transcriptional repressor, and (2) one mechanism by which CDX2 promotes anchorage-independent growth is by transcriptional repression of IGFBP-3.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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|
pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0950-9232
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
12
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pubmed:volume |
26
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4725-9
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:17297462-Cell Line, Tumor,
pubmed-meshheading:17297462-Colorectal Neoplasms,
pubmed-meshheading:17297462-Down-Regulation,
pubmed-meshheading:17297462-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:17297462-Homeodomain Proteins,
pubmed-meshheading:17297462-Humans,
pubmed-meshheading:17297462-Insulin-Like Growth Factor Binding Protein 3,
pubmed-meshheading:17297462-Insulin-Like Growth Factor Binding Proteins,
pubmed-meshheading:17297462-Promoter Regions, Genetic,
pubmed-meshheading:17297462-Repressor Proteins,
pubmed-meshheading:17297462-Transcription, Genetic,
pubmed-meshheading:17297462-Up-Regulation
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pubmed:year |
2007
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pubmed:articleTitle |
CDX2 promotes anchorage-independent growth by transcriptional repression of IGFBP-3.
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pubmed:affiliation |
Division of Hematology/Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109-0682, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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