|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0001483,
umls-concept:C0016030,
umls-concept:C0029408,
umls-concept:C0086418,
umls-concept:C0126732,
umls-concept:C0205227,
umls-concept:C0247689,
umls-concept:C0521447,
umls-concept:C0623362,
umls-concept:C1334877,
umls-concept:C1517499,
umls-concept:C1550315,
umls-concept:C1999216
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
2007-3-8
|
|
pubmed:abstractText |
To investigate the role of the transcription factor nuclear factor-kB (NF-kappaB) in promoting inflammatory and destructive responses in human osteoarthritis (OA) synovial fibroblasts, by assessing the effect of NF-kappaB blockade on the production of cytokines and destructive enzymes.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Mar
|
|
pubmed:issn |
0315-162X
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
34
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
523-33
|
|
pubmed:meshHeading |
pubmed-meshheading:17295438-ADAM Proteins,
pubmed-meshheading:17295438-Adenoviridae,
pubmed-meshheading:17295438-Aged,
pubmed-meshheading:17295438-Aged, 80 and over,
pubmed-meshheading:17295438-Cells, Cultured,
pubmed-meshheading:17295438-Female,
pubmed-meshheading:17295438-Fibroblasts,
pubmed-meshheading:17295438-Genetic Vectors,
pubmed-meshheading:17295438-Humans,
pubmed-meshheading:17295438-Inflammation Mediators,
pubmed-meshheading:17295438-Male,
pubmed-meshheading:17295438-Matrix Metalloproteinases,
pubmed-meshheading:17295438-Middle Aged,
pubmed-meshheading:17295438-NF-kappa B,
pubmed-meshheading:17295438-Osteoarthritis,
pubmed-meshheading:17295438-Procollagen N-Endopeptidase,
pubmed-meshheading:17295438-Synovial Membrane,
pubmed-meshheading:17295438-Tissue Inhibitor of Metalloproteinase-1
|
|
pubmed:year |
2007
|
|
pubmed:articleTitle |
Adenoviral gene transfer of the endogenous inhibitor IkappaBalpha into human osteoarthritis synovial fibroblasts demonstrates that several matrix metalloproteinases and aggrecanases are nuclear factor-kappaB-dependent.
|
|
pubmed:affiliation |
Department of Rheumatology; Connective Tissue Biology Laboratories, Cardiff School of Biosciences, Cardiff University, Cardiff, UK. BondesonJ@cf.ac.uk
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
