17287209

Source:http://linkedlifedata.com/resource/pubmed/id/17287209

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0005456, umls-concept:C0205314, umls-concept:C0332466, umls-concept:C0441712, umls-concept:C0530129, umls-concept:C0679622, umls-concept:C1336666, umls-concept:C1416991, umls-concept:C1523116
pubmed:issue	14
pubmed:dateCreated	2007-4-2
pubmed:abstractText	The recurrent translocation t(11;18)(q21;q21) associated with mucosa-associated lymphoid tissue (MALT) lymphoma results in the expression of an API2.MALT1 fusion protein that constitutively activates NF-kappaB. The first baculovirus IAP repeat (BIR) domain of API2 and the C terminus of MALT1, which contains its caspase-like domain, are present in all reported fusion variants and interact with TRAF2 and TRAF6, respectively, suggesting their contribution to NF-kappaB signaling by API2.MALT1. Also, the involvement of BCL10 has been suggested via binding to BIR1 of API2 and via its interaction with the immunoglobulin domains of MALT1, present in half of the fusion variants. However, conflicting reports exist concerning their roles in API2.MALT1-induced NF-kappaB signaling. In this report, streptavidin pulldowns of biotinylated API2.MALT1 fusion variants showed that none of the fusion variants interacted with endogenous BCL10; its role in NF-kappaB signaling by API2.MALT1 was further questioned by RNA interference experiments. In contrast, TRAF6 was essential for NF-kappaB activation by all fusion variants, and we identified a novel TRAF6 binding site in the second immunoglobulin domain of MALT1, which enhanced NF-kappaB activation when present in the fusion protein. Furthermore, inclusion of both immunoglobulin domains in API2.MALT1 further enhanced NF-kappaB signaling via intramolecular TRAF6 activation. Finally, binding of TRAF2 to BIR1 contributed to NF-kappaB activation by API2.MALT1, although additional mechanisms involving BIR1-mediated raft association are also important. Taken together, these data reveal distinct mechanisms of NF-kappaB activation by the different API2.MALT1 fusion variants with an essential role for TRAF6.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/2985121R
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/API2-MALT1 fusion protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing, http://linkedlifedata.com/resource/pubmed/chemical/BCL10 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Caspases, http://linkedlifedata.com/resource/pubmed/chemical/G Protein-Coupled..., http://linkedlifedata.com/resource/pubmed/chemical/KCNJ6 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/MALT1 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B, http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Oncogene Proteins, Fusion, http://linkedlifedata.com/resource/pubmed/chemical/TNF Receptor-Associated Factor 2, http://linkedlifedata.com/resource/pubmed/chemical/TNF Receptor-Associated Factor 6
pubmed:status	MEDLINE
pubmed:month	Apr
pubmed:issn	0021-9258
pubmed:author	pubmed-author:BaensMathijsM, pubmed-author:BeyaertRudiR, pubmed-author:BroeckxVickyV, pubmed-author:HagensSofieS, pubmed-author:MarynenPeterP, pubmed-author:NoelsHeidiH, pubmed-author:van LooGeertG
pubmed:issnType	Print
pubmed:day	6
pubmed:volume	282
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	10180-9
pubmed:dateRevised	2008-10-20
pubmed:meshHeading	pubmed-meshheading:17287209-Adaptor Proteins, Signal Transducing, pubmed-meshheading:17287209-Animals, pubmed-meshheading:17287209-Binding Sites, pubmed-meshheading:17287209-Caspases, pubmed-meshheading:17287209-Chromosomes, Human, Pair 11, pubmed-meshheading:17287209-Chromosomes, Human, Pair 18, pubmed-meshheading:17287209-G Protein-Coupled Inwardly-Rectifying Potassium Channels, pubmed-meshheading:17287209-Humans, pubmed-meshheading:17287209-Jurkat Cells, pubmed-meshheading:17287209-Lymphoma, B-Cell, Marginal Zone, pubmed-meshheading:17287209-NF-kappa B, pubmed-meshheading:17287209-Neoplasm Proteins, pubmed-meshheading:17287209-Oncogene Proteins, Fusion, pubmed-meshheading:17287209-Protein Binding, pubmed-meshheading:17287209-Protein Structure, Tertiary, pubmed-meshheading:17287209-Signal Transduction, pubmed-meshheading:17287209-TNF Receptor-Associated Factor 2, pubmed-meshheading:17287209-TNF Receptor-Associated Factor 6, pubmed-meshheading:17287209-Translocation, Genetic
pubmed:year	2007
pubmed:articleTitle	A Novel TRAF6 binding site in MALT1 defines distinct mechanisms of NF-kappaB activation by API2middle dotMALT1 fusions.
pubmed:affiliation	Human Genome Laboratory, Department for Molecular and Developmental Genetics, Flanders Institute for Biotechnology VIB, B-3000 Leuven, Belgium.
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't