rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
5
|
pubmed:dateCreated |
2007-4-19
|
pubmed:abstractText |
Variant surface antigens (VSA) on the surface of Plasmodium falciparum-infected red blood cells play a major role in the pathogenesis of malaria and are key targets for acquired immunity. The best-characterized VSA belong to the P. falciparum erythrocyte membrane protein 1 (PfEMP1) family. In areas where P. falciparum is endemic, parasites causing severe malaria and malaria in young children with limited immunity tend to express semiconserved PfEMP1 molecules encoded by group A var genes. Here we investigated antibody responses of Tanzanians who were 0 to 19 years old to PF11_0008, a group A PfEMP1. PF11_0008 has previously been found to be highly transcribed in a nonimmune Dutch volunteer experimentally infected with NF54 parasites. A high proportion of the Tanzanian donors had antibodies against recombinant PF11_0008 domains, and in children who were 4 to 9 years old the presence of antibodies to the PF11_0008 CIDR2beta domain was associated with reduced numbers of malaria episodes. These results indicate that homologues of PF11_0008 are present in P. falciparum field isolates and suggest that PF11_0008 CIDR2beta-reactive antibodies might be involved in protection against malaria episodes.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17283085-10086393,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/17283085-9916084
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
May
|
pubmed:issn |
0019-9567
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
75
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
2415-20
|
pubmed:dateRevised |
2009-11-18
|
pubmed:meshHeading |
pubmed-meshheading:17283085-Adolescent,
pubmed-meshheading:17283085-Adult,
pubmed-meshheading:17283085-Animals,
pubmed-meshheading:17283085-Antibodies, Protozoan,
pubmed-meshheading:17283085-Child,
pubmed-meshheading:17283085-Child, Preschool,
pubmed-meshheading:17283085-Humans,
pubmed-meshheading:17283085-Immunoglobulin G,
pubmed-meshheading:17283085-Logistic Models,
pubmed-meshheading:17283085-Malaria, Falciparum,
pubmed-meshheading:17283085-Prevalence,
pubmed-meshheading:17283085-Protozoan Proteins,
pubmed-meshheading:17283085-Recombinant Proteins,
pubmed-meshheading:17283085-Tanzania
|
pubmed:year |
2007
|