Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2007-4-19
pubmed:abstractText
Variant surface antigens (VSA) on the surface of Plasmodium falciparum-infected red blood cells play a major role in the pathogenesis of malaria and are key targets for acquired immunity. The best-characterized VSA belong to the P. falciparum erythrocyte membrane protein 1 (PfEMP1) family. In areas where P. falciparum is endemic, parasites causing severe malaria and malaria in young children with limited immunity tend to express semiconserved PfEMP1 molecules encoded by group A var genes. Here we investigated antibody responses of Tanzanians who were 0 to 19 years old to PF11_0008, a group A PfEMP1. PF11_0008 has previously been found to be highly transcribed in a nonimmune Dutch volunteer experimentally infected with NF54 parasites. A high proportion of the Tanzanian donors had antibodies against recombinant PF11_0008 domains, and in children who were 4 to 9 years old the presence of antibodies to the PF11_0008 CIDR2beta domain was associated with reduced numbers of malaria episodes. These results indicate that homologues of PF11_0008 are present in P. falciparum field isolates and suggest that PF11_0008 CIDR2beta-reactive antibodies might be involved in protection against malaria episodes.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/17283085-10086393, http://linkedlifedata.com/resource/pubmed/commentcorrection/17283085-10477742, http://linkedlifedata.com/resource/pubmed/commentcorrection/17283085-10613695, http://linkedlifedata.com/resource/pubmed/commentcorrection/17283085-10677532, http://linkedlifedata.com/resource/pubmed/commentcorrection/17283085-10714439, http://linkedlifedata.com/resource/pubmed/commentcorrection/17283085-10882604, http://linkedlifedata.com/resource/pubmed/commentcorrection/17283085-11349035, http://linkedlifedata.com/resource/pubmed/commentcorrection/17283085-11378202, http://linkedlifedata.com/resource/pubmed/commentcorrection/17283085-11544371, http://linkedlifedata.com/resource/pubmed/commentcorrection/17283085-11904437, http://linkedlifedata.com/resource/pubmed/commentcorrection/17283085-11907103, http://linkedlifedata.com/resource/pubmed/commentcorrection/17283085-11918813, http://linkedlifedata.com/resource/pubmed/commentcorrection/17283085-11930336, http://linkedlifedata.com/resource/pubmed/commentcorrection/17283085-11984002, http://linkedlifedata.com/resource/pubmed/commentcorrection/17283085-12010988, http://linkedlifedata.com/resource/pubmed/commentcorrection/17283085-12023781, http://linkedlifedata.com/resource/pubmed/commentcorrection/17283085-12368864, http://linkedlifedata.com/resource/pubmed/commentcorrection/17283085-12518849, http://linkedlifedata.com/resource/pubmed/commentcorrection/17283085-12819117, http://linkedlifedata.com/resource/pubmed/commentcorrection/17283085-12823820, http://linkedlifedata.com/resource/pubmed/commentcorrection/17283085-14565852, http://linkedlifedata.com/resource/pubmed/commentcorrection/17283085-14651589, http://linkedlifedata.com/resource/pubmed/commentcorrection/17283085-14651636, http://linkedlifedata.com/resource/pubmed/commentcorrection/17283085-14747019, http://linkedlifedata.com/resource/pubmed/commentcorrection/17283085-15123742, http://linkedlifedata.com/resource/pubmed/commentcorrection/17283085-15155661, http://linkedlifedata.com/resource/pubmed/commentcorrection/17283085-15282030, http://linkedlifedata.com/resource/pubmed/commentcorrection/17283085-15478055, http://linkedlifedata.com/resource/pubmed/commentcorrection/17283085-15857512, http://linkedlifedata.com/resource/pubmed/commentcorrection/17283085-16304608, http://linkedlifedata.com/resource/pubmed/commentcorrection/17283085-16382237, http://linkedlifedata.com/resource/pubmed/commentcorrection/17283085-16622225, http://linkedlifedata.com/resource/pubmed/commentcorrection/17283085-17015460, http://linkedlifedata.com/resource/pubmed/commentcorrection/17283085-1979090, http://linkedlifedata.com/resource/pubmed/commentcorrection/17283085-2694458, http://linkedlifedata.com/resource/pubmed/commentcorrection/17283085-3909550, http://linkedlifedata.com/resource/pubmed/commentcorrection/17283085-7541722, http://linkedlifedata.com/resource/pubmed/commentcorrection/17283085-7606788, http://linkedlifedata.com/resource/pubmed/commentcorrection/17283085-7768616, http://linkedlifedata.com/resource/pubmed/commentcorrection/17283085-8225594, http://linkedlifedata.com/resource/pubmed/commentcorrection/17283085-8622965, http://linkedlifedata.com/resource/pubmed/commentcorrection/17283085-8670911, http://linkedlifedata.com/resource/pubmed/commentcorrection/17283085-9186382, http://linkedlifedata.com/resource/pubmed/commentcorrection/17283085-9199301, http://linkedlifedata.com/resource/pubmed/commentcorrection/17283085-9500614, http://linkedlifedata.com/resource/pubmed/commentcorrection/17283085-9690477, http://linkedlifedata.com/resource/pubmed/commentcorrection/17283085-9916084
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0019-9567
pubmed:author
pubmed:issnType
Print
pubmed:volume
75
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2415-20
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2007
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