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rdf:type |
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lifeskim:mentions |
umls-concept:C0332307,
umls-concept:C0599697,
umls-concept:C0871261,
umls-concept:C1155003,
umls-concept:C1514873,
umls-concept:C1546857,
umls-concept:C1556066,
umls-concept:C1619636,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2698651,
umls-concept:C2911692
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pubmed:issue |
8
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pubmed:dateCreated |
2007-3-30
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pubmed:abstractText |
3BP2 is a pleckstrin homology domain- and Src homology 2 (SH2) domain-containing adapter protein that is mutated in the rare human bone disorder cherubism and which has also been implicated in immunoreceptor signaling. However, a function for this protein has yet to be established. Here we show that mice lacking 3BP2 exhibited a perturbation in the peritoneal B1 and splenic marginal-zone B-cell compartments and diminished thymus-independent type 2 antigen response. 3BP2(-/-) B cells demonstrated a proliferation defect in response to antigen receptor cross-linking and a heightened sensitivity to B-cell receptor-induced death via a caspase-3-dependent apoptotic pathway. We show that 3BP2 binds via its SH2 domain to the CD19 signaling complex and is required for optimum Syk phosphorylation and calcium flux.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17283041-10049356,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17283041-10193324,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17283041-10358152,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17283041-10591180,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17283041-10837064,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17283041-10933592,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17283041-11021805,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17283041-11101508,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17283041-11120811,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17283041-11371359,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17283041-11381256,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17283041-11390470,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17283041-11509691,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17283041-11733583,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17283041-11869899,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17283041-12154359,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17283041-12200378,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17283041-12387743,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17283041-12531790,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17283041-12654251,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17283041-12753744,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17283041-1379745,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17283041-14557262,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17283041-14614854,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17283041-14668867,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17283041-15075390,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17283041-15345594,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17283041-15494014,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17283041-15632178,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17283041-15771569,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17283041-16177062,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17283041-16809760,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17283041-1719083,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17283041-2472450,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17283041-3493147,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17283041-3838314,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17283041-7511210,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17283041-7552994,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17283041-7589101,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17283041-7612238,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17283041-7677187,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17283041-7684160,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17283041-7690241,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17283041-7690834,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17283041-8438166,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17283041-8553069,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17283041-8624819,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17283041-9190913,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17283041-9341782,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17283041-9620684,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17283041-9846481
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0270-7306
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
27
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3109-22
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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