Source:http://linkedlifedata.com/resource/pubmed/id/17277788
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
2007-3-7
|
| pubmed:abstractText |
We assessed the long-term outcome of patients with relapsed acute myeloid (n=86) or acute lymphoid leukemia (n=66), undergoing an allogeneic hemopoietic stem cell transplantation in our unit. The median blast count in the marrow was 30%. Conditioning regimen included total body irradiation (TBI) (10-12 Gy) in 115 patients. The donor was a matched donor (n=132) or a family mismatched donor (n=20). Twenty-two patients (15%) survive disease free, with a median follow-up of 14 years: 18 are off medications. The cumulative incidence of transplant related mortality is 40% and the cumulative incidence of relapse related death (RRD) is 45%. In multivariate analysis of survival, favorable predictors were chronic graft-versus-host disease (GvHD) (P=0.0003), donor other than family mismatched (P=0.02), donor age less than 34 years (P=0.02) and blast count less than 30% (P=0.07). Patients with all four favorable predictors had a 54% survival. In multivariate analysis of relapse, protective variables were the use of TBI (P=0.005) and cGvHD (P=0.01). This study confirms that a fraction of relapsed leukemias is cured with an allogeneic transplant: selection of patients with a blast count <30%, identification of young, human leukocyte antigen-matched donors and the use of total body radiation may significantly improve the outcome.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0268-3369
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| pubmed:author |
pubmed-author:BacigalupoAA,
pubmed-author:BreganteSS,
pubmed-author:BruniDD,
pubmed-author:DominiettoAA,
pubmed-author:FrassoniFF,
pubmed-author:GualandiFF,
pubmed-author:IbaticiAA,
pubmed-author:LamparelliTT,
pubmed-author:LombardiAA,
pubmed-author:OcchiniDD,
pubmed-author:PiaggioGG,
pubmed-author:PodestaMM,
pubmed-author:RaiolaA MAM,
pubmed-author:SacchiNN,
pubmed-author:Van LintM TMT,
pubmed-author:ViscoliCC,
pubmed-author:di GraziaCC
|
| pubmed:issnType |
Print
|
| pubmed:volume |
39
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
341-6
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| pubmed:dateRevised |
2010-11-18
|
| pubmed:meshHeading |
pubmed-meshheading:17277788-Acute Disease,
pubmed-meshheading:17277788-Adolescent,
pubmed-meshheading:17277788-Adult,
pubmed-meshheading:17277788-Bone Marrow Examination,
pubmed-meshheading:17277788-Child,
pubmed-meshheading:17277788-Female,
pubmed-meshheading:17277788-Follow-Up Studies,
pubmed-meshheading:17277788-Graft Survival,
pubmed-meshheading:17277788-Graft vs Host Disease,
pubmed-meshheading:17277788-Hematopoietic Stem Cell Transplantation,
pubmed-meshheading:17277788-Humans,
pubmed-meshheading:17277788-Kaplan-Meier Estimate,
pubmed-meshheading:17277788-Leukemia, Myeloid,
pubmed-meshheading:17277788-Male,
pubmed-meshheading:17277788-Middle Aged,
pubmed-meshheading:17277788-Neoplasm Recurrence, Local,
pubmed-meshheading:17277788-Patient Selection,
pubmed-meshheading:17277788-Precursor Cell Lymphoblastic Leukemia-Lymphoma,
pubmed-meshheading:17277788-Prognosis,
pubmed-meshheading:17277788-Survivors,
pubmed-meshheading:17277788-Transplantation, Homologous
|
| pubmed:year |
2007
|
| pubmed:articleTitle |
Allogeneic hemopoietic stem cell transplants for patients with relapsed acute leukemia: long-term outcome.
|
| pubmed:affiliation |
Divisione di Ematologia 2, Ospedale San Martino, Genova, Italy. andrea.bacigalupo@hsanmartino.it
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|