|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0011209,
umls-concept:C0012133,
umls-concept:C0019682,
umls-concept:C0019699,
umls-concept:C0033262,
umls-concept:C0205460,
umls-concept:C0220781,
umls-concept:C0220825,
umls-concept:C0439851,
umls-concept:C1522604,
umls-concept:C1552596,
umls-concept:C1883254,
umls-concept:C1947931
|
|
pubmed:issue |
8
|
|
pubmed:dateCreated |
2007-4-2
|
|
pubmed:abstractText |
Novel glycerolipidic prodrugs of didanosine and didanosine monophosphate designed to by-pass the hepatic first pass metabolism were synthesized and tested for their cytotoxicity and anti-HIV-1 activity. Formulation as liposomes of dipalmitoylphosphatidylcholine was elaborated. A simple quantitative HPLC-UV method was developed and validated, and ESI-MS was used for qualitative purpose. These two prodrugs exhibited promising biological activities against HIV-1 in in vitro infected cell culture.
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|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Apr
|
|
pubmed:issn |
0960-894X
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
15
|
|
pubmed:volume |
17
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
2237-40
|
|
pubmed:meshHeading |
pubmed-meshheading:17276686-Anti-HIV Agents,
pubmed-meshheading:17276686-Biological Availability,
pubmed-meshheading:17276686-Cells, Cultured,
pubmed-meshheading:17276686-Didanosine,
pubmed-meshheading:17276686-Drug Delivery Systems,
pubmed-meshheading:17276686-Humans,
pubmed-meshheading:17276686-Leukocytes, Mononuclear,
pubmed-meshheading:17276686-Liposomes,
pubmed-meshheading:17276686-Lymphatic System,
pubmed-meshheading:17276686-Prodrugs,
pubmed-meshheading:17276686-Purine Nucleosides,
pubmed-meshheading:17276686-Triglycerides,
pubmed-meshheading:17276686-Virus Replication
|
|
pubmed:year |
2007
|
|
pubmed:articleTitle |
Synthesis and biological evaluation of two glycerolipidic prodrugs of didanosine for direct lymphatic delivery against HIV.
|
|
pubmed:affiliation |
Université Paris-Sud, UMR CNRS 8612, IFR 141, F-92296 Châtenay-Malabry, France.
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|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
