Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2007-3-12
pubmed:abstractText
We previously have shown that forebrain inputs increase responses of amiloride-sensitive NaCl-best neurons to the conditioned stimulus (CS) in the rat parabrachial nucleus (PBN) after the establishment of conditioned taste aversion (CTA) to NaCl. In the present study, we examined the effects of aversively-conditioned NaCl taste stimulation on Fos-like immunoreactivity (FLI) in the PBN using awake intact and decerebrate rats. In Experiment 1, the CTA-trained and sham-conditioned control rats were intraorally infused with 0.1 M NaCl or 0.1 M NaCl mixed with 10(-4) M amiloride, a sodium-channel blocker. Significantly more NaCl-stimulated FLI was observed in the central medial (cms) and external lateral subnuclei (els) of PBN in the CTA-trained group than in the control group. In both groups, amiloride markedly reduced NaCl-stimulated FLI in the cms but not in the els. In Experiment 2, we found that after decerebration, there was no significant difference in FLI between the CTA-trained and sham-conditioned groups. These results suggest that (1) amirolide-sensitive taste information of NaCl projects mainly to the cms; (2) sensory information of aversive taste stimuli is likely to be represented in the els; and (3) forebrain inputs are required for elevated FLI in the PBN after CTA.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:day
13
pubmed:volume
1141
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
188-96
pubmed:meshHeading
pubmed-meshheading:17276421-Amiloride, pubmed-meshheading:17276421-Analysis of Variance, pubmed-meshheading:17276421-Animals, pubmed-meshheading:17276421-Avoidance Learning, pubmed-meshheading:17276421-Behavior, Animal, pubmed-meshheading:17276421-Conditioning, Classical, pubmed-meshheading:17276421-Decerebrate State, pubmed-meshheading:17276421-Dose-Response Relationship, Drug, pubmed-meshheading:17276421-Drug Interactions, pubmed-meshheading:17276421-Electric Stimulation, pubmed-meshheading:17276421-Immunohistochemistry, pubmed-meshheading:17276421-Male, pubmed-meshheading:17276421-Neurons, pubmed-meshheading:17276421-Oncogene Proteins v-fos, pubmed-meshheading:17276421-Pons, pubmed-meshheading:17276421-Prosencephalon, pubmed-meshheading:17276421-Rats, pubmed-meshheading:17276421-Rats, Wistar, pubmed-meshheading:17276421-Sodium Channel Blockers, pubmed-meshheading:17276421-Sodium Chloride, pubmed-meshheading:17276421-Taste
pubmed:year
2007
pubmed:articleTitle
Involvement of forebrain in parabrachial neuronal activation induced by aversively conditioned taste stimuli in the rat.
pubmed:affiliation
Department of Oral Physiology, Showa University School of Dentistry, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan. tokitak@dent.showa-u.ac.jp
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't