Linked Life Data

17265442

Source:http://linkedlifedata.com/resource/pubmed/id/17265442

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2007-5-28
pubmed:abstractText
We developed a cross-linked polyethylene (CLPE) modified with a phospholipid polymer in order to address the serious problem of osteolysis caused by wear particles derived from the polyethylene components of artificial hip joints. Our goal of preventing aseptic loosening could be achieved by avoiding any formation of CLPE wear particles or suppressing the activation of cell systems by the wear particles. We investigated the surface and wear resistance properties of 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer grafted onto the surface of CLPE (CLPE-g-MPC). The relative density of MPC polymer chains was determined by the P-O group index. Generally, polymerization times correspond to the number of polymer chains in radical polymerization. After 3.0 x 10(6) cycles in a hip joint simulator test, the steady wear rates of the untreated CLPE and CLPE-g-MPC cups with a low P-O group index were as high as 4 mg/10(6) cycles; those of the CLPE-g-MPC cups with high P-O group indexes, that is, 0.46 and 0.48, markedly decreased to -1.12 and 0.16 mg/10(6) cycles, respectively. Therefore, the grafting of an MPC polymer with high density would be essential in order to maintain the long-term wear resistance of CLPE-g-MPC as an orthopedic bearing material.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1549-3296
pubmed:author
pubmed:copyrightInfo
Copyright 2007 Wiley Periodicals, Inc.
pubmed:issnType
Print
pubmed:volume
82
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
10-7
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Enhanced wear resistance of modified cross-linked polyethylene by grafting with poly(2-methacryloyloxyethyl phosphorylcholine).
pubmed:affiliation
Research and Development Corporate Division, Japan Medical Materials Corporation, Osaka, Japan. kyomotom@jmmc.jp
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't