Linked Life Data

17264398

Source:http://linkedlifedata.com/resource/pubmed/id/17264398

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5-6
pubmed:dateCreated
2007-1-31
pubmed:abstractText
BPD_28D (O2 dependency at 28 days of life) and BPD_36W (O2 dependency at 36 wks post-menstrual age) are diseases of prematurely born infants exposed to mechanical ventilation and/or oxygen supplementation. In order to determine whether genetic variants of surfactant proteins (SPs-A, B, C, and D) and SP-B-linked microsatellite markers are risk factors in BPD, we performed a family based association study using a Greek study group of 71 neonates (<30 wks gestational age) from 60 families with, 52 BPD_28D and 19 BPD_36W, affected infants. Genotyping was performed using newly designed pyrosequencing assays and previously published methods. Associations between genetic variants of SPs and BPD subgroups were determined using Transmission Disequilibrium Test (TDT) and Family Based Association Test (FBAT). Significant associations (p<or= 0.01) were observed for alleles of SP-B and SP-B-linked microsatellite markers, and haplotypes of SP-A, SP-D, and SP-B. Specifically, allele B-18_C associated with susceptibility in BPD_36W. Microsatellite marker AAGG_6 associated with susceptibility in BPD_28D/36W group. Haplotype analysis revealed ten susceptibility and one protective haplotypes for SP-B and SP-B-linked microsatellite markers and two SP-A-SP-D protective haplotypes. The data indicate that SP loci are linked to BPD. Studies in different study groups and/or of larger sample size are warranted to confirm these observations and delineate genetic background of BPD subgroups.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0278-0240
pubmed:author
pubmed:issnType
Print
pubmed:volume
22
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
277-91
pubmed:dateRevised
2007-12-3
pubmed:meshHeading
pubmed-meshheading:17264398-Alleles, pubmed-meshheading:17264398-Bronchopulmonary Dysplasia, pubmed-meshheading:17264398-Female, pubmed-meshheading:17264398-Genetic Markers, pubmed-meshheading:17264398-Genetic Predisposition to Disease, pubmed-meshheading:17264398-Genotype, pubmed-meshheading:17264398-Haplotypes, pubmed-meshheading:17264398-Humans, pubmed-meshheading:17264398-Infant, Newborn, pubmed-meshheading:17264398-Male, pubmed-meshheading:17264398-Microsatellite Repeats, pubmed-meshheading:17264398-Polymorphism, Single Nucleotide, pubmed-meshheading:17264398-Pulmonary Surfactant-Associated Protein A, pubmed-meshheading:17264398-Pulmonary Surfactant-Associated Protein B, pubmed-meshheading:17264398-Pulmonary Surfactant-Associated Protein C, pubmed-meshheading:17264398-Pulmonary Surfactant-Associated Protein D, pubmed-meshheading:17264398-Pulmonary Surfactant-Associated Proteins, pubmed-meshheading:17264398-Sequence Analysis, DNA
pubmed:year
2006
pubmed:articleTitle
Genetic variants of surfactant proteins A, B, C, and D in bronchopulmonary dysplasia.
pubmed:affiliation
Department of Cellular and Molecular Physiology, PSU, Hershey, PA 17033, USA.
pubmed:publicationType
Journal Article, Research Support, N.I.H., Extramural