Source:http://linkedlifedata.com/resource/pubmed/id/17259737
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
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| pubmed:dateCreated |
2007-4-13
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| pubmed:databankReference | |
| pubmed:abstractText |
Although the majority of hepatitis E virus (HEV) infections in Japan are 'domestic' due to the presence of indigenous strains, there are still 'imported' cases as well. Among 83 patients with non-A, non-B and non-C acute liver diseases admitted to Saitama Medical University Hospital, 7 (8.4%) were positive for serum HEV-RNA, of whom 2 had a recent history of traveling to China, one to Xian and another to Shanghai. We determined the full-genome sequences of HEV from these 2 patients (isolate names are JKO-ChiSai98c and JYI-ChiSai01c, genotype 4 in both) for phylogenetic analyses. Initially, when compared only to the 13 full-genome sequences of genotype 4 so far reported, our 2 isolates were thought to be novel strains because they showed a significant genetic difference from the sequences known to date. However, when we included a set of short sequences (150 nt) recently reported from China in the comparison, we found that our 2 isolates represent a subgroup of genotype 4, which seems to be restricted to eastern China. In conclusion, the 2 HEV isolates reported here could serve as full-genome prototypes for an eastern China-indigenous subgroup of the genotype 4 HEV.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:issn |
0300-5526
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| pubmed:author | |
| pubmed:copyrightInfo |
(c) 2007 S. Karger AG, Basel.
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| pubmed:issnType |
Print
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| pubmed:volume |
50
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
181-9
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| pubmed:meshHeading |
pubmed-meshheading:17259737-Adult,
pubmed-meshheading:17259737-Aged,
pubmed-meshheading:17259737-Aged, 80 and over,
pubmed-meshheading:17259737-Base Sequence,
pubmed-meshheading:17259737-China,
pubmed-meshheading:17259737-Female,
pubmed-meshheading:17259737-Genome, Viral,
pubmed-meshheading:17259737-Genotype,
pubmed-meshheading:17259737-Hepatitis E,
pubmed-meshheading:17259737-Hepatitis E virus,
pubmed-meshheading:17259737-Histocytochemistry,
pubmed-meshheading:17259737-Humans,
pubmed-meshheading:17259737-Japan,
pubmed-meshheading:17259737-Liver,
pubmed-meshheading:17259737-Male,
pubmed-meshheading:17259737-Middle Aged,
pubmed-meshheading:17259737-Molecular Sequence Data,
pubmed-meshheading:17259737-Phylogeny,
pubmed-meshheading:17259737-RNA, Viral,
pubmed-meshheading:17259737-Sequence Analysis, DNA,
pubmed-meshheading:17259737-Sequence Homology,
pubmed-meshheading:17259737-Travel
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| pubmed:year |
2007
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| pubmed:articleTitle |
Full-length sequences of two hepatitis E virus isolates representing an Eastern China-indigenous subgroup of genotype 4.
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| pubmed:affiliation |
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Saitama Medical University, Saitama, Japan.
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| pubmed:publicationType |
Journal Article
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