Linked Life Data

17248993

Source:http://linkedlifedata.com/resource/pubmed/id/17248993

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2010-6-28
pubmed:abstractText
A statistical genetic model of a multivariate phenotype is derived to investigate the covariation of pleiotropic mutations with additive effects under the combined action of phenotypic selection, linkage and the mating system. Equilibrium formulas for large, randomly mating populations demonstrate that, when selection on polygenic variation is much smaller than twice the harmonic mean recombination rate between loci with interacting fitnesses, linkage disequilibrium is negligible and pleiotropy is the main cause of genetic correlations between characters. Under these conditions, approximate expressions for the dynamics of the genetic covariances due to pleiotropic mutations are obtained. Patterns of genetic covariance between characters and their evolution are discussed with reference to data on polygenic mutation, chromosomal organization and morphological integration.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:status
PubMed-not-MEDLINE
pubmed:month
Jan
pubmed:issn
0016-6731
pubmed:author
pubmed:issnType
Print
pubmed:volume
94
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
203-15
pubmed:dateRevised
2010-9-15
pubmed:year
1980
pubmed:articleTitle
The Genetic Covariance between Characters Maintained by Pleiotropic Mutations.
pubmed:affiliation
Laboratory of Genetics, University of Wisconsin, Madison, Wisconsin.
pubmed:publicationType
Journal Article