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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2007-2-23
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pubmed:abstractText |
N(1)-Arylsulfonyl-substituted analogs of N,N-dimethyltryptamine bind at 5-HT(6) receptors. Replacement of the aryl moiety with similarly hydrophobic alkyl substituents results in decreased affinity, as does replacement of a benzenesulfonyl moiety with a benzyl group. Current findings indicate that an aryl (or substituted aryl) sulfonyl (rather than alkylsulfonyl or benzyl) moiety is optimal for high-affinity binding, and further suggest that the N(1)-benzenesulfonyl- and their corresponding N(1)-benzyltryptamine counterparts bind in a different fashion.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0960-894X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1691-4
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pubmed:dateRevised |
2007-12-3
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pubmed:meshHeading |
pubmed-meshheading:17239595-Chromatography, Thin Layer,
pubmed-meshheading:17239595-DNA, Complementary,
pubmed-meshheading:17239595-Humans,
pubmed-meshheading:17239595-Indicators and Reagents,
pubmed-meshheading:17239595-Magnetic Resonance Spectroscopy,
pubmed-meshheading:17239595-Receptors, Serotonin,
pubmed-meshheading:17239595-Structure-Activity Relationship,
pubmed-meshheading:17239595-Tryptamines
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pubmed:year |
2007
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pubmed:articleTitle |
Further studies on the binding of N1-substituted tryptamines at h5-HT6 receptors.
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pubmed:affiliation |
Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, Richmond, VA 23298-0540, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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