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rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
6
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pubmed:dateCreated |
2007-2-23
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|
pubmed:abstractText |
Derivatives of indolo[2,1-b]quinazolinone containing aminoalkylamino side chains were synthesized as specific DNA triplex stabilizing agents. The aminoalkylamino side chains are essential for triplex stabilization. The position-8 fluorine atom or a methyl group to the nitrogen adjacent to the planar core can enhance triplex stability by 6 degrees C and the effect is additive. Conformational analysis reveals that the orientation of the side chain underlies the ability of this compound to stabilize a DNA triplex.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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|
pubmed:month |
Mar
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pubmed:issn |
0960-894X
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:day |
15
|
|
pubmed:volume |
17
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
1769-72
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:17239588-Chemistry, Physical,
pubmed-meshheading:17239588-Circular Dichroism,
pubmed-meshheading:17239588-DNA,
pubmed-meshheading:17239588-Indoles,
pubmed-meshheading:17239588-Ligands,
pubmed-meshheading:17239588-Nucleic Acid Conformation,
pubmed-meshheading:17239588-Physicochemical Phenomena,
pubmed-meshheading:17239588-Quinazolines,
pubmed-meshheading:17239588-Spectrophotometry, Ultraviolet
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|
pubmed:year |
2007
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|
pubmed:articleTitle |
Specific stabilization of DNA triple helices by indolo[2,1-b]quinazolin-6,12-dione derivatives.
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|
pubmed:affiliation |
Department of Applied Chemistry, Providence University, Sha-Lu 43301, Taiwan, ROC.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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