Forebrain dopamine (DA) manipulation has recently been shown to selectively disrupt a conditional discrimination task whose design parameters approximate tasks repeatedly shown to be impaired in schizophrenia.
Clozapine, SCH 23390 and alpha-flupenthixol but not haloperidol attenuate acute phencyclidine-induced disruption of conditional discrimination performance.
Department of Health and Social Sciences (Psychology), University of Wales Institute Cardiff (UWIC), Llandaff Campus, Western Avenue, Cardiff, CF5 2SG, UK. mdunn@uwic.ac.uk