| pubmed-article:17237239 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17237239 | lifeskim:mentions | umls-concept:C1882687 | lld:lifeskim |
| pubmed-article:17237239 | lifeskim:mentions | umls-concept:C1955862 | lld:lifeskim |
| pubmed-article:17237239 | lifeskim:mentions | umls-concept:C0332206 | lld:lifeskim |
| pubmed-article:17237239 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:17237239 | pubmed:dateCreated | 2007-5-9 | lld:pubmed |
| pubmed-article:17237239 | pubmed:abstractText | The present study was conducted to determine whether the infarct sparing effect of short-term exercise is dependent on the operation of the myocardial sarcolemmal ATP-sensitive K(+) (K(ATP)) channel. Adult male and female Sprague-Dawley rats were exercised on a motorized treadmill for 5 days. Twenty-four hours following the training or sedentary period, hearts were isolated and exposed to 1 h of regional ischemia followed by 2 h of reperfusion on a modified Langendorf apparatus in the presence or absence of the sarcolemmal K(ATP) channel antagonist HMR-1098 (30 microM). Following the ischemia-reperfusion protocol, infarct size was determined as a percentage of the total ischemic zone at risk (ZAR). Short-term exercise reduced infarct size by 24% in males (32 +/- 2% of ZAR; P < 0.01) and by 18% in females (26 +/- 2% of ZAR; P < 0.05). Sarcolemmal K(ATP) channel blockade abolished the training-induced cardioprotection in both males and females, increasing infarct size to 43 +/- 3% and 52 +/- 4% of ZAR, respectively. In the absence of HMR-1098, infarct size was significantly lower in sedentary females than in males (33 +/- 4% vs. 42 +/- 2% of ZAR, respectively; P < 0.01). However, the presence of HMR-1098 abolished this sex difference, increasing infarct size by 58% in the sedentary females (P < 0.01) but having no effect on infarct size in sedentary males. This study demonstrates that the sex-specific and exercise-acquired resistance to myocardial ischemia-reperfusion injury is dependent on sarcolemmal K(ATP) activity during ischemia. | lld:pubmed |
| pubmed-article:17237239 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17237239 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17237239 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17237239 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17237239 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17237239 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17237239 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17237239 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17237239 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17237239 | pubmed:month | May | lld:pubmed |
| pubmed-article:17237239 | pubmed:issn | 0363-6135 | lld:pubmed |
| pubmed-article:17237239 | pubmed:author | pubmed-author:MooreRussell... | lld:pubmed |
| pubmed-article:17237239 | pubmed:author | pubmed-author:LynchJoshua... | lld:pubmed |
| pubmed-article:17237239 | pubmed:author | pubmed-author:ArmstrongCase... | lld:pubmed |
| pubmed-article:17237239 | pubmed:author | pubmed-author:JohnsonMicah... | lld:pubmed |
| pubmed-article:17237239 | pubmed:author | pubmed-author:ChiccoAdam... | lld:pubmed |
| pubmed-article:17237239 | pubmed:author | pubmed-author:GardnerRyan... | lld:pubmed |
| pubmed-article:17237239 | pubmed:author | pubmed-author:FasenGeoff... | lld:pubmed |
| pubmed-article:17237239 | pubmed:author | pubmed-author:GillenwaterCo... | lld:pubmed |
| pubmed-article:17237239 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17237239 | pubmed:volume | 292 | lld:pubmed |
| pubmed-article:17237239 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17237239 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17237239 | pubmed:pagination | H2432-7 | lld:pubmed |
| pubmed-article:17237239 | pubmed:dateRevised | 2007-12-3 | lld:pubmed |
| pubmed-article:17237239 | pubmed:meshHeading | pubmed-meshheading:17237239... | lld:pubmed |
| pubmed-article:17237239 | pubmed:meshHeading | pubmed-meshheading:17237239... | lld:pubmed |
| pubmed-article:17237239 | pubmed:meshHeading | pubmed-meshheading:17237239... | lld:pubmed |
| pubmed-article:17237239 | pubmed:meshHeading | pubmed-meshheading:17237239... | lld:pubmed |
| pubmed-article:17237239 | pubmed:meshHeading | pubmed-meshheading:17237239... | lld:pubmed |
| pubmed-article:17237239 | pubmed:meshHeading | pubmed-meshheading:17237239... | lld:pubmed |
| pubmed-article:17237239 | pubmed:meshHeading | pubmed-meshheading:17237239... | lld:pubmed |
| pubmed-article:17237239 | pubmed:meshHeading | pubmed-meshheading:17237239... | lld:pubmed |
| pubmed-article:17237239 | pubmed:meshHeading | pubmed-meshheading:17237239... | lld:pubmed |
| pubmed-article:17237239 | pubmed:meshHeading | pubmed-meshheading:17237239... | lld:pubmed |
| pubmed-article:17237239 | pubmed:meshHeading | pubmed-meshheading:17237239... | lld:pubmed |
| pubmed-article:17237239 | pubmed:meshHeading | pubmed-meshheading:17237239... | lld:pubmed |
| pubmed-article:17237239 | pubmed:meshHeading | pubmed-meshheading:17237239... | lld:pubmed |
| pubmed-article:17237239 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17237239 | pubmed:articleTitle | Sex-specific and exercise-acquired cardioprotection is abolished by sarcolemmal KATP channel blockade in the rat heart. | lld:pubmed |
| pubmed-article:17237239 | pubmed:affiliation | Department of Integrative Physiology, University of Colorado at Boulder, Boulder, CO 80309, USA. | lld:pubmed |
| pubmed-article:17237239 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17237239 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:17237239 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17237239 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17237239 | lld:pubmed |
