|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
2007-3-19
|
|
pubmed:abstractText |
Genetic studies in the mouse have implicated ephrin-B2 (encoded by the gene Efnb2) in blood vessel formation, cardiac development and remodeling of the lymphatic vasculature. Here we report that loss of ephrin-B2 leads to defects in populations of cranial and trunk neural crest cells (NCC) and to defective somite development. In addition, we show that Efnb1/Efnb2 double heterozygous embryos exhibit phenotypes in a number of NCC derivatives. Expression of one copy of a mutant version of Efnb2 that lacks tyrosine phosphorylation sites was sufficient to rescue the embryonic phenotypes associated with loss of Efnb2. Our results uncover an important role for ephrin-B2 in NCC and somites during embryogenesis and suggest that ephrin-B2 exerts many of its embryonic function via activation of forward signaling.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17223098-10601038,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17223098-10725243,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17223098-10725246,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17223098-10774725,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17223098-11163240,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17223098-11301003,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17223098-11306625,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17223098-11557983,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17223098-11784098,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17223098-11830568,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17223098-11983165,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17223098-12217323,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17223098-12450221,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17223098-12808016,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17223098-12919674,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17223098-13678588,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17223098-14517207,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17223098-14986683,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17223098-15037550,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17223098-15223333,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17223098-15313393,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17223098-15469835,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17223098-15561600,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17223098-15580616,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17223098-15687262,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17223098-15809040,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17223098-15882579,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17223098-15928710,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17223098-15950606,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17223098-16314868,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17223098-16319111,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17223098-16511561,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17223098-16728472,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17223098-8231879,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17223098-8269518,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17223098-8878483,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17223098-8947026,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17223098-9054357,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17223098-9115733,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17223098-9259557,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17223098-9259560,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17223098-9412504,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17223098-9630219,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17223098-9765210,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17223098-9920925,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17223098-9990854
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Apr
|
|
pubmed:issn |
0012-1606
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
1
|
|
pubmed:volume |
304
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
182-93
|
|
pubmed:dateRevised |
2011-9-26
|
|
pubmed:meshHeading |
pubmed-meshheading:17223098-Animals,
pubmed-meshheading:17223098-Body Patterning,
pubmed-meshheading:17223098-DNA Primers,
pubmed-meshheading:17223098-Ephrin-B2,
pubmed-meshheading:17223098-Fluorescent Antibody Technique,
pubmed-meshheading:17223098-Immunohistochemistry,
pubmed-meshheading:17223098-In Situ Hybridization,
pubmed-meshheading:17223098-Mice,
pubmed-meshheading:17223098-Neural Crest,
pubmed-meshheading:17223098-Signal Transduction,
pubmed-meshheading:17223098-Somites
|
|
pubmed:year |
2007
|
|
pubmed:articleTitle |
Ephrin-B2 forward signaling regulates somite patterning and neural crest cell development.
|
|
pubmed:affiliation |
Program in Developmental Biology, Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N., Seattle, WA 98109, USA.
|
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, N.I.H., Extramural
|
