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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2007-1-17
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pubmed:abstractText |
The molecular mechanisms underlying the formation of neurons with defined neurotransmitters are not well understood. In this study, we demonstrate that the PcG-like genes in Caenorhabditis elegans, sop-2 and sor-3, regulate the formation of dopaminergic and serotonergic neurons and several other neuronal properties. sor-3 encodes a novel protein containing an MBT repeat, a domain that contains histone-binding activity and is present in PcG proteins SCM and Sfmbt in other organisms. We further show that mutations in sor-3 lead to ectopic expression of Hox genes and cause homeotic transformations. Specification of certain neuronal identities by these PcG-like genes appears to involve regulation of non-Hox gene targets. Our studies revealed that the PcG-like genes are crucial for coordinately regulating the expression of discrete aspects of neuronal identities in C. elegans.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17215367-10049576,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17215367-10072377,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17215367-10637628,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17215367-10676966,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17215367-11560780,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17215367-12791274,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17215367-15081363,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17215367-15337121,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17215367-15959558,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17215367-16618800,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17215367-16618801,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17215367-16624900,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17215367-7635288,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17215367-9598363,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17215367-9755199,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17215367-9880574
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Caenorhabditis elegans Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Egl-5 protein, C elegans,
http://linkedlifedata.com/resource/pubmed/chemical/Gene Products, vif,
http://linkedlifedata.com/resource/pubmed/chemical/Homeodomain Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin,
http://linkedlifedata.com/resource/pubmed/chemical/Sop-2 protein, C elegans,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta,
http://linkedlifedata.com/resource/pubmed/chemical/lin-39 protein, C elegans
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
16
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pubmed:volume |
104
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
852-7
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:17215367-Amino Acid Motifs,
pubmed-meshheading:17215367-Amino Acid Sequence,
pubmed-meshheading:17215367-Animals,
pubmed-meshheading:17215367-Caenorhabditis elegans,
pubmed-meshheading:17215367-Caenorhabditis elegans Proteins,
pubmed-meshheading:17215367-DNA-Binding Proteins,
pubmed-meshheading:17215367-Dopamine,
pubmed-meshheading:17215367-Gene Products, vif,
pubmed-meshheading:17215367-Homeodomain Proteins,
pubmed-meshheading:17215367-Molecular Sequence Data,
pubmed-meshheading:17215367-Mutation,
pubmed-meshheading:17215367-Neurons,
pubmed-meshheading:17215367-Phenotype,
pubmed-meshheading:17215367-Repressor Proteins,
pubmed-meshheading:17215367-Sequence Alignment,
pubmed-meshheading:17215367-Sequence Homology, Amino Acid,
pubmed-meshheading:17215367-Serotonin,
pubmed-meshheading:17215367-Signal Transduction,
pubmed-meshheading:17215367-Transcription Factors,
pubmed-meshheading:17215367-Transforming Growth Factor beta
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pubmed:year |
2007
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pubmed:articleTitle |
Polycomb-like genes are necessary for specification of dopaminergic and serotonergic neurons in Caenorhabditis elegans.
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pubmed:affiliation |
National Institute of Biological Sciences, Zhongguancun Life Science Park, No. 7 Science Park Road, Beijing 102206, People's Republic of China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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