Linked Life Data

17192496

Source:http://linkedlifedata.com/resource/pubmed/id/17192496

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2006-12-28
pubmed:abstractText
This study determined the oral bioavailability of mycophenolic acid, the active metabolite of mycophenolate mofetil, in patients undergoing nonmyeloablative hematopoietic cell transplantation. Eighteen adults receiving a preparative regimen containing fludarabine, cyclophosphamide, and total body irradiation were studied. Immune suppression consisted of cyclosporine and mycophenolate 1 g twice daily. Pharmacokinetic variability was high after intravenous and oral dosing. Intravenous dosing resulted in a median area under the curve (AUC) of 28.3 microg x h/mL (range, 9.96-70.4) and an oral AUC of 16.7 microg x h/mL (range, 9.38-35.3). Cmax after intravenous and oral dosing was 12.18 and 5.29 microg/mL, respectively. The median oral bioavailability was 72.3% (20.5%-172%), with 8-fold variability. Five patients (28%) had an oral bioavailability < or = 50%. At time of oral pharmacokinetics, 15 patients (83%) had an AUC(0-12) < 30 microg x h/mL. The initial oral dose should be at least 25% greater than the intravenous dose with follow-up assessment of plasma concentrations.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0091-2700
pubmed:author
pubmed:issnType
Print
pubmed:volume
47
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
6-12
pubmed:dateRevised
2011-9-22
pubmed:meshHeading
pubmed-meshheading:17192496-Administration, Oral, pubmed-meshheading:17192496-Adult, pubmed-meshheading:17192496-Aged, pubmed-meshheading:17192496-Area Under Curve, pubmed-meshheading:17192496-Biological Availability, pubmed-meshheading:17192496-Cyclophosphamide, pubmed-meshheading:17192496-Cyclosporine, pubmed-meshheading:17192496-Female, pubmed-meshheading:17192496-Hematopoietic Stem Cell Transplantation, pubmed-meshheading:17192496-Humans, pubmed-meshheading:17192496-Immunosuppressive Agents, pubmed-meshheading:17192496-Injections, Intravenous, pubmed-meshheading:17192496-Male, pubmed-meshheading:17192496-Middle Aged, pubmed-meshheading:17192496-Mycophenolic Acid, pubmed-meshheading:17192496-Statistics, Nonparametric, pubmed-meshheading:17192496-Vidarabine, pubmed-meshheading:17192496-Whole-Body Irradiation
pubmed:year
2007
pubmed:articleTitle
Highly variable mycophenolate mofetil bioavailability following nonmyeloablative hematopoietic cell transplantation.
pubmed:affiliation
Department of Experimental and Clinical Pharmacology, Weaver Densford Hall 7-189, 308 Harvard Street SE, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA.
pubmed:publicationType
Journal Article, Clinical Trial, Comparative Study