Linked Life Data

17190461

Source:http://linkedlifedata.com/resource/pubmed/id/17190461

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2006-12-27
pubmed:abstractText
A new dimeric withanolide, ashwagandhanolide (1), was isolated from the roots of an Ayurvedic medicinal herb, Withania somnifera. A detailed spectroscopic evaluation revealed its identity as a dimer with an unusual thioether linkage. Compound 1 displayed growth inhibition against human gastric (AGS), breast (MCF-7), central nervous system (SF-268), colon (HCT-116), and lung (NCI H460) cancer cell lines, with IC50 values in the range 0.43-1.48 microg/mL. In addition, it inhibited lipid peroxidation and the activity of the enzyme cyclooxygenase-2 in vitro.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0163-3864
pubmed:author
pubmed:issnType
Print
pubmed:volume
69
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1790-2
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Ashwagandhanolide, a bioactive dimeric thiowithanolide isolated from the roots of Withania somnifera.
pubmed:affiliation
Laila Research Center, Unit I, Phase III, Jawahar Autonagar, Vijayawada 520 007, India. subbarajugottumukkala@hotmail.com
pubmed:publicationType
Journal Article