Linked Life Data

17189679

Source:http://linkedlifedata.com/resource/pubmed/id/17189679

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pubmed-article:17189679pubmed:abstractTextRecently, we have shown a differential susceptibility of non-pathogenic vs. pathogenic leptospires to phagocytosis and killing by microglial cells. Although all ingested to some extent, only the pathogenic strains survived intracellularly while the non-pathogenic ones were killed in a time-dependent manner. By the same infection model, here we demonstrate that microglial cells respond to Leptospira infection with a time- and dose-dependent induction of molecular signals (p38 phosphorilation and NF-kB activation) and the production of soluble factors (cytokines and nitric oxide). Such bio-molecular response is predominantly observed against the pathogenic Leptospira; the phenomenon is reproduced by leptospiral lipoproteins and, to a lower extent, by leptospiral-derived LPS. These data provide initial evidence that Leptospira affects microglial cell response in a different manner depending upon the virulence of the infecting strain; specific bacterial components happen to be involved in the induction of such pathogen-induced immune response.lld:pubmed
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pubmed-article:17189679pubmed:dateRevised2009-11-19lld:pubmed
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pubmed-article:17189679pubmed:articleTitleNF-kB activation and p38 phosphorilation in microglial cells infected with Leptospira or exposed to partially purified leptospiral lipoproteins.lld:pubmed
pubmed-article:17189679pubmed:affiliationDipartimento di Scienze di Sanità Pubblica, Università di Modena e Reggio Emilia, Via Campi 287, 41100 Modena, Italy. blasi.elisabetta@unimore.itlld:pubmed
pubmed-article:17189679pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:17189679pubmed:publicationTypeComparative Studylld:pubmed
pubmed-article:17189679pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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