Source:http://linkedlifedata.com/resource/pubmed/id/17185358
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
2007-3-2
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pubmed:abstractText |
Herpes stromal keratitis (HSK) is an immunopathological disease regulated by Th1 CD4 T cells, which require APC and costimulation within the infected cornea to mediate disease. Recent studies suggest the OX40:OX40 ligand (OX40L) interaction enhances effector cell cytokine secretion at inflammatory sites. OX40(+) cells were detected in HSV-1-infected mouse corneas as early as 3 days postinfection (dpi), prior to the onset of HSK, and their frequency increased through 15 dpi, when all mice exhibited severe HSK. OX40L(+) cells were first detected at 7 dpi, coincident with the initiation of HSK. It is interesting that the OX40L(+) cells did not coexpress MHC Class II or the dendritic cell (DC) marker CD11c. Our findings demonstrate rapid infiltration of activated (OX40(+)) CD4(+) T cells into HSV-1-infected corneas and expression of OX40L on MHC Class II-negative cells but surprisingly, not on MHC Class II(+) CD11c(+) DC, which are present in the infected corneas and required for HSK. Moreover, neither local nor systemic treatment of mice with a blocking antibody to OX40L or with a blocking fusion protein altered the course of HSK significantly, possibly as a result of a lack of OX40L expression on functional APC.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, OX40,
http://linkedlifedata.com/resource/pubmed/chemical/Tnfrsf4 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Tnfsf4 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factors
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0741-5400
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
81
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
766-74
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pubmed:meshHeading |
pubmed-meshheading:17185358-Animals,
pubmed-meshheading:17185358-Antibodies,
pubmed-meshheading:17185358-Cornea,
pubmed-meshheading:17185358-Female,
pubmed-meshheading:17185358-Gene Expression Profiling,
pubmed-meshheading:17185358-Herpesvirus 1, Human,
pubmed-meshheading:17185358-Inflammation,
pubmed-meshheading:17185358-Keratitis, Herpetic,
pubmed-meshheading:17185358-Membrane Glycoproteins,
pubmed-meshheading:17185358-Mice,
pubmed-meshheading:17185358-Mice, Inbred BALB C,
pubmed-meshheading:17185358-RNA, Messenger,
pubmed-meshheading:17185358-Receptors, OX40,
pubmed-meshheading:17185358-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:17185358-Tumor Necrosis Factors
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pubmed:year |
2007
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pubmed:articleTitle |
Expression and function of the OX40/OX40L costimulatory pair during herpes stromal keratitis.
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pubmed:affiliation |
Department of Ophthalmology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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