| pubmed-article:17183426 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17183426 | lifeskim:mentions | umls-concept:C0002395 | lld:lifeskim |
| pubmed-article:17183426 | lifeskim:mentions | umls-concept:C0027746 | lld:lifeskim |
| pubmed-article:17183426 | lifeskim:mentions | umls-concept:C0025646 | lld:lifeskim |
| pubmed-article:17183426 | lifeskim:mentions | umls-concept:C0814299 | lld:lifeskim |
| pubmed-article:17183426 | lifeskim:mentions | umls-concept:C1521739 | lld:lifeskim |
| pubmed-article:17183426 | lifeskim:mentions | umls-concept:C0449379 | lld:lifeskim |
| pubmed-article:17183426 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:17183426 | pubmed:dateCreated | 2006-12-21 | lld:pubmed |
| pubmed-article:17183426 | pubmed:abstractText | Clinical manifestation of Alzheimer's disease may depend upon interaction among its risk factors. Apolipoprotein E-deficient mice undergo oxidative damage and cognitive impairment when deprived of folate. We demonstrate herein that these mice were depleted in the methyl donor S-adenosyl methionine (SAM), which inhibited glutathione S-transferase, since this enzyme requires methylation of oxidative species prior to glutathione-dependent reduction. Dietary supplementation with SAM alleviated neuropathology. Since SAM deficiency promotes presenilin-1 overexpression, which increases gamma-secretase expression and Abeta generation, these findings directly link nutritional deficiency and genetic risk factors, and support supplementation with SAM for Alzheimer's therapy. | lld:pubmed |
| pubmed-article:17183426 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17183426 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17183426 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17183426 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17183426 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17183426 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17183426 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17183426 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17183426 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17183426 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17183426 | pubmed:issn | 1279-7707 | lld:pubmed |
| pubmed-article:17183426 | pubmed:author | pubmed-author:GravesMM | lld:pubmed |
| pubmed-article:17183426 | pubmed:author | pubmed-author:ChanAA | lld:pubmed |
| pubmed-article:17183426 | pubmed:author | pubmed-author:SheaT BTB | lld:pubmed |
| pubmed-article:17183426 | pubmed:author | pubmed-author:RogersEE | lld:pubmed |
| pubmed-article:17183426 | pubmed:author | pubmed-author:OrtizDD | lld:pubmed |
| pubmed-article:17183426 | pubmed:author | pubmed-author:TchantchouFF | lld:pubmed |
| pubmed-article:17183426 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17183426 | pubmed:volume | 10 | lld:pubmed |
| pubmed-article:17183426 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17183426 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17183426 | pubmed:pagination | 541-4 | lld:pubmed |
| pubmed-article:17183426 | pubmed:meshHeading | pubmed-meshheading:17183426... | lld:pubmed |
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| pubmed-article:17183426 | pubmed:meshHeading | pubmed-meshheading:17183426... | lld:pubmed |
| pubmed-article:17183426 | pubmed:meshHeading | pubmed-meshheading:17183426... | lld:pubmed |
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| pubmed-article:17183426 | pubmed:meshHeading | pubmed-meshheading:17183426... | lld:pubmed |
| pubmed-article:17183426 | pubmed:meshHeading | pubmed-meshheading:17183426... | lld:pubmed |
| pubmed-article:17183426 | pubmed:meshHeading | pubmed-meshheading:17183426... | lld:pubmed |
| pubmed-article:17183426 | pubmed:meshHeading | pubmed-meshheading:17183426... | lld:pubmed |
| pubmed-article:17183426 | pubmed:articleTitle | S-adenosyl methionine: A connection between nutritional and genetic risk factors for neurodegeneration in Alzheimer's disease. | lld:pubmed |
| pubmed-article:17183426 | pubmed:affiliation | Center for Cellular Neurobiology and Neurodegeneration Research, Department of Biological Sciences, UMassLowell, One University Avenue, Lowell, MA 01854, USA. | lld:pubmed |
| pubmed-article:17183426 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17183426 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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