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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2006-12-21
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pubmed:abstractText |
Clinical manifestation of Alzheimer's disease may depend upon interaction among its risk factors. Apolipoprotein E-deficient mice undergo oxidative damage and cognitive impairment when deprived of folate. We demonstrate herein that these mice were depleted in the methyl donor S-adenosyl methionine (SAM), which inhibited glutathione S-transferase, since this enzyme requires methylation of oxidative species prior to glutathione-dependent reduction. Dietary supplementation with SAM alleviated neuropathology. Since SAM deficiency promotes presenilin-1 overexpression, which increases gamma-secretase expression and Abeta generation, these findings directly link nutritional deficiency and genetic risk factors, and support supplementation with SAM for Alzheimer's therapy.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1279-7707
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
541-4
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pubmed:meshHeading |
pubmed-meshheading:17183426-Adenosine,
pubmed-meshheading:17183426-Alzheimer Disease,
pubmed-meshheading:17183426-Animals,
pubmed-meshheading:17183426-Apolipoproteins E,
pubmed-meshheading:17183426-Disease Models, Animal,
pubmed-meshheading:17183426-Enzyme Inhibitors,
pubmed-meshheading:17183426-Ethionine,
pubmed-meshheading:17183426-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:17183426-Glutathione Transferase,
pubmed-meshheading:17183426-Mice,
pubmed-meshheading:17183426-Mice, Knockout,
pubmed-meshheading:17183426-Oxidative Stress,
pubmed-meshheading:17183426-Risk Factors,
pubmed-meshheading:17183426-Vitamin E Deficiency
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pubmed:articleTitle |
S-adenosyl methionine: A connection between nutritional and genetic risk factors for neurodegeneration in Alzheimer's disease.
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pubmed:affiliation |
Center for Cellular Neurobiology and Neurodegeneration Research, Department of Biological Sciences, UMassLowell, One University Avenue, Lowell, MA 01854, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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