Linked Life Data

1718334

Source:http://linkedlifedata.com/resource/pubmed/id/1718334

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1991-11-29
pubmed:abstractText
N-methyl-D-aspartate (NMDA) and non-NMDA receptors play a key role in synaptic transmission and plasticity in the vertebrate central nervous system. Previous studies have suggested that although both receptor types are present at synapses, the NMDA receptors may be relatively uniformly distributed. We have combined iontophoretic mapping of NMDA and non-NMDA receptors with immunohistochemical localization of synaptic vesicles along dendrites of single neocortical neurons to determine the relationship between NMDA and non-NMDA receptor distribution and the location of synapses. We find that when corrections for glutamate diffusion are made, NMDA responses are concentrated at focal "hot spots" that coincide with non-NMDA hot spots and that there is an excellent correlation between these hot spots and synapses.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0896-6273
pubmed:author
pubmed:issnType
Print
pubmed:volume
7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
593-603
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Both NMDA and non-NMDA subtypes of glutamate receptors are concentrated at synapses on cerebral cortical neurons in culture.
pubmed:affiliation
Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't