Linked Life Data

17183269

Source:http://linkedlifedata.com/resource/pubmed/id/17183269

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7123
pubmed:dateCreated
2007-1-4
pubmed:abstractText
We observe that the time of appearance of cellular compartmentalization correlates with atmospheric oxygen concentration. To explore this correlation, we predict and characterize the topology of all transmembrane proteins in 19 taxa and correlate differences in topology with historical atmospheric oxygen concentrations. Here we show that transmembrane proteins, individually and as a group, were probably selectively excluding oxygen in ancient ancestral taxa, and that this constraint decreased over time when atmospheric oxygen levels rose. As this constraint decreased, the size and number of communication-related transmembrane proteins increased. We suggest the hypothesis that atmospheric oxygen concentrations affected the timing of the evolution of cellular compartmentalization by constraining the size of domains necessary for communication across membranes.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1476-4687
pubmed:author
pubmed:issnType
Electronic
pubmed:day
4
pubmed:volume
445
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
47-52
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Oxygen content of transmembrane proteins over macroevolutionary time scales.
pubmed:affiliation
Max Planck Institute for Plant Breeding Research, Carl-von-Linnè-Weg 10, 50829 Köln, Germany. Claudia.Acquisti.1@asu.edu
pubmed:publicationType
Journal Article