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rdf:type |
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lifeskim:mentions |
umls-concept:C0006556,
umls-concept:C0007600,
umls-concept:C0009368,
umls-concept:C0017262,
umls-concept:C0018837,
umls-concept:C0059392,
umls-concept:C0086418,
umls-concept:C0185117,
umls-concept:C0204727,
umls-concept:C0205360,
umls-concept:C0205409,
umls-concept:C0598546,
umls-concept:C2911684
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pubmed:issue |
3
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pubmed:dateCreated |
1991-11-1
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pubmed:databankReference |
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pubmed:abstractText |
Heat stable enterotoxins (STs) are low molecular-weight peptides secreted by enterotoxigenic bacteria. One type of these enterotoxins (STa) induces intestinal secretion leading to acute diarrhea by binding to a membrane form of guanylate cyclase. We have isolated a cDNA from a human colonic cell line, T84, encoding for a guanylate cyclase-coupled enterotoxin receptor (STaR). The predicted amino acid sequence of the human STa receptor is 81% identical with the previously cloned enterotoxin receptor (GC-C) from rat intestine. COS-7 cells transiently transfected with the cloned cDNA expressed specific concentration-dependent response to STa as measured by cyclic GMP accumulation and is about 20 times more sensitive to the stimulation by STa than has been shown for GC-C.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic GMP,
http://linkedlifedata.com/resource/pubmed/chemical/DNA,
http://linkedlifedata.com/resource/pubmed/chemical/Guanylate Cyclase,
http://linkedlifedata.com/resource/pubmed/chemical/RNA,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Guanylate Cyclase-Coupled,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Peptide,
http://linkedlifedata.com/resource/pubmed/chemical/enterotoxin receptor
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0006-291X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
30
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pubmed:volume |
179
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1455-63
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:1718270-Amino Acid Sequence,
pubmed-meshheading:1718270-Animals,
pubmed-meshheading:1718270-Base Sequence,
pubmed-meshheading:1718270-Cell Line,
pubmed-meshheading:1718270-Colon,
pubmed-meshheading:1718270-Cyclic GMP,
pubmed-meshheading:1718270-DNA,
pubmed-meshheading:1718270-Gene Library,
pubmed-meshheading:1718270-Guanylate Cyclase,
pubmed-meshheading:1718270-Humans,
pubmed-meshheading:1718270-Kinetics,
pubmed-meshheading:1718270-Molecular Sequence Data,
pubmed-meshheading:1718270-RNA,
pubmed-meshheading:1718270-Rats,
pubmed-meshheading:1718270-Receptors, Cell Surface,
pubmed-meshheading:1718270-Receptors, Guanylate Cyclase-Coupled,
pubmed-meshheading:1718270-Receptors, Peptide,
pubmed-meshheading:1718270-Sequence Homology, Nucleic Acid,
pubmed-meshheading:1718270-Transfection
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pubmed:year |
1991
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pubmed:articleTitle |
Isolation and expression of a guanylate cyclase-coupled heat stable enterotoxin receptor cDNA from a human colonic cell line.
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pubmed:affiliation |
Klinikum Innenstadt, Universität, München, Germany.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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