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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2007-4-23
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pubmed:abstractText |
We investigated the Akt-mTOR pathway and effects of rapamycin using human colorectal cancer cell lines. LoVo and CaRI reduced proliferative activity in response to rapamycin in a dose-dependent manner. The phosphorylation of Akt and p70 S6K was prominent in these cells. Rapamycin quickly downregulated phospho-S6K but not phospho-Akt. Therefore, phospho-S6K is considered a good indicator of the activated Akt-mTOR pathway as well as rapamycin sensitivity in colorectal cancer cells. By immunohistochemical study, nearly 40% of adenomas and carcinomas of the colorectum exhibited either partial or whole positive staining for phospho-S6K, suggestive of rapamycin-sensitive lesions.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibiotics, Antineoplastic,
http://linkedlifedata.com/resource/pubmed/chemical/Ki-67 Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/MTOR protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-akt,
http://linkedlifedata.com/resource/pubmed/chemical/Ribosomal Protein S6 Kinases, 70-kDa,
http://linkedlifedata.com/resource/pubmed/chemical/Sirolimus,
http://linkedlifedata.com/resource/pubmed/chemical/TOR Serine-Threonine Kinases
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0304-3835
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
18
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pubmed:volume |
251
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
105-13
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:17175097-Antibiotics, Antineoplastic,
pubmed-meshheading:17175097-Apoptosis,
pubmed-meshheading:17175097-Blotting, Western,
pubmed-meshheading:17175097-Cell Line, Tumor,
pubmed-meshheading:17175097-Cell Proliferation,
pubmed-meshheading:17175097-Colorectal Neoplasms,
pubmed-meshheading:17175097-Dose-Response Relationship, Drug,
pubmed-meshheading:17175097-Flow Cytometry,
pubmed-meshheading:17175097-Humans,
pubmed-meshheading:17175097-Immunohistochemistry,
pubmed-meshheading:17175097-Ki-67 Antigen,
pubmed-meshheading:17175097-Phosphorylation,
pubmed-meshheading:17175097-Protein Kinases,
pubmed-meshheading:17175097-Proto-Oncogene Proteins c-akt,
pubmed-meshheading:17175097-Ribosomal Protein S6 Kinases, 70-kDa,
pubmed-meshheading:17175097-Signal Transduction,
pubmed-meshheading:17175097-Sirolimus,
pubmed-meshheading:17175097-TOR Serine-Threonine Kinases
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pubmed:year |
2007
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pubmed:articleTitle |
Phosphorylation of ribosomal p70 S6 kinase and rapamycin sensitivity in human colorectal cancer.
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pubmed:affiliation |
Department of Surgical Oncology, University of Tokyo, 7-3-1 Hongo, Bunkyu-ku, Tokyo 113-8655, Japan. hiroanozawa-gi@umin.ac.jp <hiroanozawa-gi@umin.ac.jp>
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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