Linked Life Data

17170061

Source:http://linkedlifedata.com/resource/pubmed/id/17170061

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2007-8-31
pubmed:abstractText
Clozapine use has been notably lower in African American patients than in Caucasians. It has been suggested that lower normal ranges for white blood cell (WBC) counts in African Americans, known as benign ethnic neutropenia, may account partially for the disparity. We examined the rates of leucopenia and agranulocytosis as reasons for discontinuation of clozapine in a sample of 1875 patients with schizophrenia treated in the State of Maryland. Between 1989 and 1999, 5.3% (31/588) of African Americans and 2.4% (31/1287) of Caucasians discontinued clozapine treatment due to leucopenia (chi square = 10.35, df = 1, P = 0.001). No African American patients developed agranulocytosis while 8 Caucasian patients (0.62%) developed this blood dyscrasia. Discontinuations due to leucopenia occurred throughout treatment. Discontinuations due to agranulocytosis occurred primarily in the first 18 weeks (7/8; 87.5% patients with agranulocytosis). It is likely that African Americans had clozapine discontinued unnecessarily due to benign ethnic neutropenia. We concur with recent recommendations to acknowledge differences in WBC values in African Americans and to modify prescribing guidelines or formally acknowledge benign ethnic leucopenia like in other countries in order to facilitate greater use of clozapine in these patients.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/17170061-10789357, http://linkedlifedata.com/resource/pubmed/commentcorrection/17170061-11743944, http://linkedlifedata.com/resource/pubmed/commentcorrection/17170061-14514496, http://linkedlifedata.com/resource/pubmed/commentcorrection/17170061-14600298, http://linkedlifedata.com/resource/pubmed/commentcorrection/17170061-15076018, http://linkedlifedata.com/resource/pubmed/commentcorrection/17170061-15746507, http://linkedlifedata.com/resource/pubmed/commentcorrection/17170061-16191206, http://linkedlifedata.com/resource/pubmed/commentcorrection/17170061-16399976, http://linkedlifedata.com/resource/pubmed/commentcorrection/17170061-16520022, http://linkedlifedata.com/resource/pubmed/commentcorrection/17170061-16585434, http://linkedlifedata.com/resource/pubmed/commentcorrection/17170061-17017827, http://linkedlifedata.com/resource/pubmed/commentcorrection/17170061-8515788, http://linkedlifedata.com/resource/pubmed/commentcorrection/17170061-8881919, http://linkedlifedata.com/resource/pubmed/commentcorrection/17170061-8939137
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0586-7614
pubmed:author
pubmed:issnType
Print
pubmed:volume
33
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1221-4
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Clozapine underutilization and discontinuation in African Americans due to leucopenia.
pubmed:affiliation
The Maryland Psychiatric Research Center, Box 21247, Baltimore, MD 21228, USA. dkelly@mprc.umaryland.edu
pubmed:publicationType
Journal Article, Comparative Study, Research Support, N.I.H., Extramural