Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
35
pubmed:dateCreated
2006-12-15
pubmed:abstractText
A severe atypical pneumonia designated as severe acute respiratory syndrome (SARS) by The World Health Organization broke out in China and menaced to more than other 30 countries between the end of the year 2002 and June of the year 2003. A novel coronavirus called severe acute respiratory syndrome coronavirus (SARS-CoV) has been recently identified as the etiological agent responsible for the infectious SARS disease. Based on extensively scientific cooperation and almost two-year's studies, remarkable achievements have been made in the understanding of the phylogenetic property and the genome organization of SARS-CoV, as well as the detailed characters of the major proteins involved in SARS-CoV life cycle. In this review, we would like to summarize the substantial scientific progress that has been made towards the structural and functional aspects of SARS-CoV associated key proteins. The progress focused on the corresponding key proteins' structure-based drug and vaccine developments has been also highlighted. The concerted and cooperative response for the treatment of the SARS disease has been proved to be a triumph of global public health and provides a new paradigm for the detection and control of future emerging infectious disease threats.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/3C-like protease, SARS coronavirus, http://linkedlifedata.com/resource/pubmed/chemical/Antiviral Agents, http://linkedlifedata.com/resource/pubmed/chemical/Cysteine Endopeptidases, http://linkedlifedata.com/resource/pubmed/chemical/E protein, SARS coronavirus, http://linkedlifedata.com/resource/pubmed/chemical/M protein, Coronavirus, http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins, http://linkedlifedata.com/resource/pubmed/chemical/Nucleocapsid Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Viral Envelope Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Viral Matrix Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Viral Nonstructural Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Viral Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Viral Vaccines, http://linkedlifedata.com/resource/pubmed/chemical/nucleocapsid protein, Coronavirus, http://linkedlifedata.com/resource/pubmed/chemical/spike glycoprotein, coronavirus
pubmed:status
MEDLINE
pubmed:issn
1873-4286
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4539-53
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
An overall picture of SARS coronavirus (SARS-CoV) genome-encoded major proteins: structures, functions and drug development.
pubmed:affiliation
Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 201203, China.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't