Linked Life Data

1716672

Source:http://linkedlifedata.com/resource/pubmed/id/1716672

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1991-10-22
pubmed:abstractText
We describe here the growth rate, morphology and ultrastructure of the RN6 neurinoma spheroids in culture and after syngeneic transplantation under the renal capsule of adult BDIX rats, where sequential growth and tumour angiogenesis studies were performed. The tumour cells in solid avascular multicell spheroids (MTS) and in subrenal capsule tumours (SCT) showed similar morphology and ultrastructure. The vascularization of spheroids started 2 to 3 days after implantation under the renal capsule from proliferating venule-like vessels of the kidney parenchyma. The MTS were soon densely penetrated by hairpin loops of newly formed capillaries. Such vascularized spheroids grew rapidly. The morphology, ultrastructure and permeability characteristics of newly formed tumour vessels and their relationship to the development of tumour necrosis are described. This syngeneic model of subrenal capsule transplantation of neurogenic tumour spheroids appears to be useful for studies of the mechanisms of tumour angiogenesis, tumour necroses and the host response to malignant tumours of the nervous system.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0167-594X
pubmed:author
pubmed:issnType
Print
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
219-31
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Development of subrenal capsule tumours following transplantation of rat RN6 multicell spheroids.
pubmed:affiliation
Department of Neuropathology, University of Düsseldorf, Germany.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't