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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2007-4-16
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pubmed:abstractText |
Cell cycle progression beyond the G1/S phase transition requires the activation of a transcription complex containing histone nuclear factor P (HiNF-P) and nuclear protein mapped to ataxia telangiectasia (p220(NPAT)) in response to cyclin dependent kinase 2 (CDK2)/cyclin E signaling. We show here that the potent co-activating properties of HiNF-P/p220(NPAT) on the histone H4 gene promoter, which are evident in the majority of human cell types, are sporadically neutralized in distinct somatic cell lines. In cells where HiNF-P and p220(NPAT) do not activate the H4 gene promoter, HiNF-P instead represses transcription. Our data suggest that the cell type specific expression of the cyclin-dependent kinase inhibitory (CKI) protein p57(KIP2) inhibits the HiNF-P dependent activation of the histone H4 promoter. We propose that, analogous to E2F proteins and other cell cycle regulatory proteins, HiNF-P is a bifunctional transcriptional regulator that can activate or repress cell cycle controlled genes depending on the cellular context.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0730-2312
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pubmed:author |
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pubmed:copyrightInfo |
(c) 2006 Wiley-Liss, Inc.
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
101
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
181-91
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:17163457-Animals,
pubmed-meshheading:17163457-COS Cells,
pubmed-meshheading:17163457-Cell Cycle,
pubmed-meshheading:17163457-Cell Cycle Proteins,
pubmed-meshheading:17163457-Cell Line,
pubmed-meshheading:17163457-Cell Line, Transformed,
pubmed-meshheading:17163457-Cell Line, Tumor,
pubmed-meshheading:17163457-Cell Transformation, Viral,
pubmed-meshheading:17163457-Cercopithecus aethiops,
pubmed-meshheading:17163457-Cyclin-Dependent Kinase Inhibitor p57,
pubmed-meshheading:17163457-Genes, Reporter,
pubmed-meshheading:17163457-HeLa Cells,
pubmed-meshheading:17163457-Histones,
pubmed-meshheading:17163457-Humans,
pubmed-meshheading:17163457-Luciferases,
pubmed-meshheading:17163457-Nuclear Proteins,
pubmed-meshheading:17163457-Promoter Regions, Genetic,
pubmed-meshheading:17163457-Repressor Proteins,
pubmed-meshheading:17163457-Transcription, Genetic,
pubmed-meshheading:17163457-Transfection
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pubmed:year |
2007
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pubmed:articleTitle |
HiNF-P is a bifunctional regulator of cell cycle controlled histone H4 gene transcription.
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pubmed:affiliation |
Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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