Source:http://linkedlifedata.com/resource/pubmed/id/17162649
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
9
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| pubmed:dateCreated |
2006-12-12
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| pubmed:abstractText |
The authors investigated whether autologous bone marrow mononuclear cell (BMC) transplantation via the left and right main bronchi would mitigate elastase-induced pulmonary emphysema in rabbits. Four weeks after elastase administration, rabbits also receiving BMCs showed significantly better pulmonary function (FVC, FEV100, FEVPEF) and smaller alveolar airspaces, as indicated by a smaller mean linear intercept, than those receiving porcine pancreatic elastase (PPE) (200 U/kg) alone via the left and right main bronchi. BMCs also significantly reduced cell counts in bronchoalveolar lavage fluid, the incidence of apoptotic (TUNEL-positive) cells and matrix metalloproteinase (MMP)-2 expression, while increasing numbers of proliferative (Ki-67-positive) cells. Thus, BMCs may inhibit the progression to emphysema by attenuating inflammation, MMP-2 expression, and apoptosis, while enhancing alveolar cell proliferation.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
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| pubmed:issn |
0190-2148
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
32
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
413-26
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| pubmed:meshHeading |
pubmed-meshheading:17162649-Animals,
pubmed-meshheading:17162649-Apoptosis,
pubmed-meshheading:17162649-Bone Marrow Transplantation,
pubmed-meshheading:17162649-Bronchoalveolar Lavage Fluid,
pubmed-meshheading:17162649-Cell Count,
pubmed-meshheading:17162649-Disease Models, Animal,
pubmed-meshheading:17162649-Emphysema,
pubmed-meshheading:17162649-Fluorescent Antibody Technique, Indirect,
pubmed-meshheading:17162649-Immunoenzyme Techniques,
pubmed-meshheading:17162649-Ki-67 Antigen,
pubmed-meshheading:17162649-Lung,
pubmed-meshheading:17162649-Male,
pubmed-meshheading:17162649-Matrix Metalloproteinase 2,
pubmed-meshheading:17162649-Monocytes,
pubmed-meshheading:17162649-Pancreatic Elastase,
pubmed-meshheading:17162649-Pulmonary Alveoli,
pubmed-meshheading:17162649-Rabbits,
pubmed-meshheading:17162649-Respiratory Function Tests,
pubmed-meshheading:17162649-Transplantation, Autologous
|
| pubmed:year |
2006
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| pubmed:articleTitle |
Beneficial effects of autologous bone marrow mononuclear cell transplantation against elastase-induced emphysema in rabbits.
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| pubmed:affiliation |
Second Department of Internal Medicine, Regeneration and Advanced Medical Science, Graduate School of Medicine, Gifu University, Gifu, Japan.
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| pubmed:publicationType |
Journal Article
|