Linked Life Data

17152009

Source:http://linkedlifedata.com/resource/pubmed/id/17152009

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2006-12-7
pubmed:abstractText
Gene networks of protective lymphocytes after immune activation with live attenuated vaccines remain poorly characterized. Because Mycobacterium bovis bacille Calmette-Guérin (BCG) vaccine can confer protection against fatal forms of tuberculosis in humans and monkeys, we made use of macaque models to optimally study immune gene networks after BCG vaccination/infection. We first established and validated a large-scale real-time quantitation system and then used it to measure expression levels of 138 immune genes after BCG vaccination/infection of rhesus macaques. Systemic BCG vaccination induced up to 600-fold increases in expression of 78 immune genes among the 138 genes tested at the time when BCG-elicited T cell responses and immunity were apparent. These up-regulated transcripts constituted multiple gene networks that were linked to various aspects of immune function. Surprisingly, the up-regulation of most of these immune genes in the gene networks occurred at 1 week and was sustained at > or = 6 weeks after BCG vaccination/infection. Although early activation of immune gene networks was an immune correlate of anti-BCG immunity, prolonged up-regulation of these networks coincided with the development of vaccine-elicited T cell responses after BCG vaccination/infection. These findings provide molecular evidence suggesting that the BCG-induced gene networks may represent global transcriptomes and proteomes underlying the development of T cell responses and, ultimately, immunity to mycobacteria.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/17152009-10517722, http://linkedlifedata.com/resource/pubmed/commentcorrection/17152009-10644334, http://linkedlifedata.com/resource/pubmed/commentcorrection/17152009-11312343, http://linkedlifedata.com/resource/pubmed/commentcorrection/17152009-11345212, http://linkedlifedata.com/resource/pubmed/commentcorrection/17152009-11471829, http://linkedlifedata.com/resource/pubmed/commentcorrection/17152009-11507214, http://linkedlifedata.com/resource/pubmed/commentcorrection/17152009-11796622, http://linkedlifedata.com/resource/pubmed/commentcorrection/17152009-11861596, http://linkedlifedata.com/resource/pubmed/commentcorrection/17152009-11910108, http://linkedlifedata.com/resource/pubmed/commentcorrection/17152009-12584325, http://linkedlifedata.com/resource/pubmed/commentcorrection/17152009-12869023, http://linkedlifedata.com/resource/pubmed/commentcorrection/17152009-14498983, http://linkedlifedata.com/resource/pubmed/commentcorrection/17152009-14767808, http://linkedlifedata.com/resource/pubmed/commentcorrection/17152009-15367608, http://linkedlifedata.com/resource/pubmed/commentcorrection/17152009-15378436, http://linkedlifedata.com/resource/pubmed/commentcorrection/17152009-15528324, http://linkedlifedata.com/resource/pubmed/commentcorrection/17152009-15557180, http://linkedlifedata.com/resource/pubmed/commentcorrection/17152009-15564509, http://linkedlifedata.com/resource/pubmed/commentcorrection/17152009-15708990, http://linkedlifedata.com/resource/pubmed/commentcorrection/17152009-15771580, http://linkedlifedata.com/resource/pubmed/commentcorrection/17152009-15821738, http://linkedlifedata.com/resource/pubmed/commentcorrection/17152009-16243089, http://linkedlifedata.com/resource/pubmed/commentcorrection/17152009-16257251, http://linkedlifedata.com/resource/pubmed/commentcorrection/17152009-16260489, http://linkedlifedata.com/resource/pubmed/commentcorrection/17152009-16296870, http://linkedlifedata.com/resource/pubmed/commentcorrection/17152009-16403511, http://linkedlifedata.com/resource/pubmed/commentcorrection/17152009-16428800, http://linkedlifedata.com/resource/pubmed/commentcorrection/17152009-16458769, http://linkedlifedata.com/resource/pubmed/commentcorrection/17152009-16491140, http://linkedlifedata.com/resource/pubmed/commentcorrection/17152009-16497578, http://linkedlifedata.com/resource/pubmed/commentcorrection/17152009-16754722, http://linkedlifedata.com/resource/pubmed/commentcorrection/17152009-4632221, http://linkedlifedata.com/resource/pubmed/commentcorrection/17152009-4632222, http://linkedlifedata.com/resource/pubmed/commentcorrection/17152009-4985917, http://linkedlifedata.com/resource/pubmed/commentcorrection/17152009-5000470, http://linkedlifedata.com/resource/pubmed/commentcorrection/17152009-7596718, http://linkedlifedata.com/resource/pubmed/commentcorrection/17152009-8144299, http://linkedlifedata.com/resource/pubmed/commentcorrection/17152009-8309034, http://linkedlifedata.com/resource/pubmed/commentcorrection/17152009-8568249, http://linkedlifedata.com/resource/pubmed/commentcorrection/17152009-8610692
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0022-1899
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
195
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
55-69
pubmed:dateRevised
2010-9-14
pubmed:meshHeading
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