|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
2007-1-8
|
|
pubmed:abstractText |
Adenoviruses can cause severe toxicity in immunocompromised individuals. Although clinical trials have confirmed the potency and safety of selectively oncolytic adenoviruses for treatment of advanced cancers, increasingly effective agents could result in more toxicity and therefore it would be useful if replication could be abrogated if necessary.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jan
|
|
pubmed:issn |
1099-498X
|
|
pubmed:author |
pubmed-author:DesmondRenee ARA,
pubmed-author:HöckerstedtKristerK,
pubmed-author:HelinAijaA,
pubmed-author:HemminkiAkseliA,
pubmed-author:IsoniemiHelenaH,
pubmed-author:KanervaAnnaA,
pubmed-author:KoponenJarmoJ,
pubmed-author:RakiMariM,
pubmed-author:RankiTuuliT,
pubmed-author:RistimäkiAriA,
pubmed-author:SärkiojaMerjaM,
pubmed-author:StenmanUlf-HåkanUH
|
|
pubmed:copyrightInfo |
Copyright 2006 John Wiley & Sons, Ltd.
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
9
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
3-9
|
|
pubmed:meshHeading |
pubmed-meshheading:17149790-Adenocarcinoma,
pubmed-meshheading:17149790-Adenoviridae,
pubmed-meshheading:17149790-Animals,
pubmed-meshheading:17149790-Apigenin,
pubmed-meshheading:17149790-Chlorpromazine,
pubmed-meshheading:17149790-Female,
pubmed-meshheading:17149790-Humans,
pubmed-meshheading:17149790-Liver,
pubmed-meshheading:17149790-Mice,
pubmed-meshheading:17149790-Mice, Nude,
pubmed-meshheading:17149790-Oncolytic Virotherapy,
pubmed-meshheading:17149790-Oncolytic Viruses,
pubmed-meshheading:17149790-Ovarian Neoplasms,
pubmed-meshheading:17149790-Toxicity Tests,
pubmed-meshheading:17149790-Tumor Cells, Cultured,
pubmed-meshheading:17149790-Virus Replication
|
|
pubmed:year |
2007
|
|
pubmed:articleTitle |
Chlorpromazine and apigenin reduce adenovirus replication and decrease replication associated toxicity.
|
|
pubmed:affiliation |
Cancer Gene Therapy Group, Rational Drug Design Program and Haartman Institute, University of Helsinki, Finland.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
