Linked Life Data

17149609

Source:http://linkedlifedata.com/resource/pubmed/id/17149609

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2007-4-20
pubmed:abstractText
Nuclear factor-kappaB (NF-kappaB) plays a crucial role in the regulation of inflammatory processes, cell proliferation, and apoptosis. Blocking NF-kappaB signaling may represent a therapeutic strategy in cancer and inflammation therapy. The aim of this study was to investigate the effects of sesquiterpenes isolated from Asteraceae, namely melampolides (enhydrin, tetraludin A) and repandolides (repandins A, B, D and E) on the activation of NF-kappaB, cell growth of cancer cells, cell cycle progression and apoptosis. In addition, their effects on the activity of cyclooxygenase-2 (COX-2) enzyme were also evaluated.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0344-5704
pubmed:author
pubmed:issnType
Print
pubmed:volume
60
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
35-43
pubmed:meshHeading
pubmed-meshheading:17149609-Apoptosis, pubmed-meshheading:17149609-Asteraceae, pubmed-meshheading:17149609-Cell Cycle, pubmed-meshheading:17149609-Cell Line, pubmed-meshheading:17149609-Cell Line, Tumor, pubmed-meshheading:17149609-Cyclooxygenase 2, pubmed-meshheading:17149609-Cyclooxygenase 2 Inhibitors, pubmed-meshheading:17149609-Dose-Response Relationship, Drug, pubmed-meshheading:17149609-G2 Phase, pubmed-meshheading:17149609-HL-60 Cells, pubmed-meshheading:17149609-Humans, pubmed-meshheading:17149609-Inhibitory Concentration 50, pubmed-meshheading:17149609-Lactones, pubmed-meshheading:17149609-Luciferases, pubmed-meshheading:17149609-Macrophages, pubmed-meshheading:17149609-Microscopy, Fluorescence, pubmed-meshheading:17149609-Molecular Structure, pubmed-meshheading:17149609-NF-kappa B, pubmed-meshheading:17149609-Plant Extracts, pubmed-meshheading:17149609-Sesquiterpenes, pubmed-meshheading:17149609-Sp1 Transcription Factor, pubmed-meshheading:17149609-Tetradecanoylphorbol Acetate, pubmed-meshheading:17149609-Transcription, Genetic
pubmed:year
2007
pubmed:articleTitle
Inhibition of NF-kappaB-mediated transcription and induction of apoptosis by melampolides and repandolides.
pubmed:affiliation
National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, MS 38677, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S.