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rdf:type |
|
|
lifeskim:mentions |
|
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pubmed:issue |
3
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|
pubmed:dateCreated |
1991-9-26
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|
pubmed:abstractText |
The macrolide FK-506, produced by Streptomyces tsukubaensis, is effective in sensitizing a multidrug resistant strain of Chinese hamster ovary cells to the cytotoxic action of vinblastine. FK-506 also promotes Adriamycin accumulation into both wild type and resistant cell lines. FK-506 may be a useful drug to enhance the effectiveness of anti-tumour cytotoxic drugs.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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|
pubmed:month |
Jul
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pubmed:issn |
0266-9536
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
6
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pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
189-93
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|
pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1714737-Animals,
pubmed-meshheading:1714737-Anti-Bacterial Agents,
pubmed-meshheading:1714737-Biological Transport,
pubmed-meshheading:1714737-Cell Line,
pubmed-meshheading:1714737-Cell Survival,
pubmed-meshheading:1714737-Cricetinae,
pubmed-meshheading:1714737-Cricetulus,
pubmed-meshheading:1714737-Dose-Response Relationship, Drug,
pubmed-meshheading:1714737-Doxorubicin,
pubmed-meshheading:1714737-Drug Resistance,
pubmed-meshheading:1714737-Immunosuppressive Agents,
pubmed-meshheading:1714737-Tacrolimus,
pubmed-meshheading:1714737-Vinblastine
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|
pubmed:year |
1991
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|
pubmed:articleTitle |
The new potent immunosuppressant FK-506 reverses multidrug resistance in Chinese hamster ovary cells.
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pubmed:affiliation |
Department of Biochemistry, McMaster University, Hamilton, Ontario, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
