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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
16
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pubmed:dateCreated |
1991-9-18
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pubmed:abstractText |
Adherence of human eosinophils to cytokine-stimulated endothelial cells, which was only partially due to CD18-dependent pathways, was also mediated by binding to endothelial leukocyte adhesion molecule 1 (ELAM-1) and vascular cell adhesion molecule 1 (VCAM-1). Eosinophils bound specifically to both recombinant soluble ELAM-1 and recombinant soluble VCAM-1. Eosinophil binding to recombinant soluble VCAM-1 and to transfected CHO cells expressing VCAM-1 was inhibited with anti-VCAM-1 (4B9) and anti-very late activation antigen 4 (anti-VLA-4; HP1/2 or HP2/1) monoclonal antibodies. Eosinophils, but not neutrophils, expressed VLA-4 detected by cytofluorography. Eosinophil adherence to tumor necrosis factor alpha-stimulated human umbilical vein endothelial cells was partially blocked by monoclonal antibodies against ELAM-1 (BB11) and VCAM-1 (4B9) and against VLA-4 (HP2/1). Thus, while both eosinophils and neutrophils can bind to activated endothelial cells by adherence to ICAM-1 and ELAM-1, only eosinophils expressed VLA-4 and adhered to VCAM-1 on activated endothelial cells. Eosinophil adherence to VCAM-1 might provide a mechanism contributing to the selective recruitment of eosinophils into tissue sites of inflammation.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1714604-1689216,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1714604-1695647,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1714604-1697461,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1714604-1697486,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1714604-1697696,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1714604-1698865,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1714604-1702034,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1714604-1702804,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1714604-1702807,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1714604-1704191,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1714604-1711067,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1714604-1851800,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1714604-1967851,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1714604-1968426,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1714604-1977836,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1714604-2116236,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1714604-2188667,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1714604-2196321,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1714604-2252260,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1714604-2428877,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1714604-2430809,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1714604-2460564,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1714604-2543245,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1714604-2688898,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1714604-2785856,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1714604-2974055,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1714604-3279115,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1714604-3497921,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1714604-3900232,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1714604-6644024
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
88
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
7430-3
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:1714604-Cell Adhesion,
pubmed-meshheading:1714604-Cell Adhesion Molecules,
pubmed-meshheading:1714604-Cells, Cultured,
pubmed-meshheading:1714604-E-Selectin,
pubmed-meshheading:1714604-Endothelium, Vascular,
pubmed-meshheading:1714604-Eosinophils,
pubmed-meshheading:1714604-Humans,
pubmed-meshheading:1714604-Neutrophils,
pubmed-meshheading:1714604-Protein Binding,
pubmed-meshheading:1714604-Tumor Necrosis Factor-alpha,
pubmed-meshheading:1714604-Umbilical Veins,
pubmed-meshheading:1714604-Vascular Cell Adhesion Molecule-1
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pubmed:year |
1991
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pubmed:articleTitle |
Human eosinophil adherence to vascular endothelium mediated by binding to vascular cell adhesion molecule 1 and endothelial leukocyte adhesion molecule 1.
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pubmed:affiliation |
Department of Medicine, Charles A. Dana Research Institute, Beth Israel Hospital, Harvard Medical School, Boston, MA 02215.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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