Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
Pt 5
pubmed:dateCreated
2007-4-5
pubmed:abstractText
Plasmodium malariae, a protozoan parasite that causes malaria in humans, has a global distribution in tropical and subtropical regions and is commonly found in sympatry with other Plasmodium species of humans. Little is known about the genetics or population structure of P. malariae. In the present study, we describe polymorphic genetic markers for P. malariae and present the first molecular epidemiological data for this parasite. Six microsatellite or minisatellite markers were validated using 76 P. malariae samples from a diverse geographical range. The repeat unit length varied from 2 to 17 bp, and up to 10 different alleles per locus were detected. Multiple genotypes of P. malariae were detected in 33 of 70 samples from humans with naturally acquired infection. Heterozygosity was calculated to be between 0.236 and 0.811. Allelic diversity was reduced for samples from South America and, at some loci, in samples from Thailand compared with those from Malawi. The number of unique multilocus genotypes defined using the 6 markers was significantly greater in Malawi than in Thailand, even when data from single genotype infections were used. There was a significant reduction in the multiplicity of infection in symptomatic infections compared with asymptomatic ones, suggesting that clinical episodes are usually caused by the expansion of a single genotype.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/17140466-10348249, http://linkedlifedata.com/resource/pubmed/commentcorrection/17140466-10413040, http://linkedlifedata.com/resource/pubmed/commentcorrection/17140466-10432043, http://linkedlifedata.com/resource/pubmed/commentcorrection/17140466-10450421, http://linkedlifedata.com/resource/pubmed/commentcorrection/17140466-10466118, http://linkedlifedata.com/resource/pubmed/commentcorrection/17140466-10481157, http://linkedlifedata.com/resource/pubmed/commentcorrection/17140466-10547834, http://linkedlifedata.com/resource/pubmed/commentcorrection/17140466-10548283, http://linkedlifedata.com/resource/pubmed/commentcorrection/17140466-10581610, http://linkedlifedata.com/resource/pubmed/commentcorrection/17140466-10632997, http://linkedlifedata.com/resource/pubmed/commentcorrection/17140466-10657296, http://linkedlifedata.com/resource/pubmed/commentcorrection/17140466-10697834, http://linkedlifedata.com/resource/pubmed/commentcorrection/17140466-10726261, http://linkedlifedata.com/resource/pubmed/commentcorrection/17140466-10813477, http://linkedlifedata.com/resource/pubmed/commentcorrection/17140466-10877649, http://linkedlifedata.com/resource/pubmed/commentcorrection/17140466-10915089, http://linkedlifedata.com/resource/pubmed/commentcorrection/17140466-11018154, http://linkedlifedata.com/resource/pubmed/commentcorrection/17140466-11085245, http://linkedlifedata.com/resource/pubmed/commentcorrection/17140466-11127243, http://linkedlifedata.com/resource/pubmed/commentcorrection/17140466-11355566, http://linkedlifedata.com/resource/pubmed/commentcorrection/17140466-11425185, http://linkedlifedata.com/resource/pubmed/commentcorrection/17140466-11463113, http://linkedlifedata.com/resource/pubmed/commentcorrection/17140466-12054010, http://linkedlifedata.com/resource/pubmed/commentcorrection/17140466-12114045, http://linkedlifedata.com/resource/pubmed/commentcorrection/17140466-12452496, http://linkedlifedata.com/resource/pubmed/commentcorrection/17140466-12798085, http://linkedlifedata.com/resource/pubmed/commentcorrection/17140466-12824352, http://linkedlifedata.com/resource/pubmed/commentcorrection/17140466-12832643, http://linkedlifedata.com/resource/pubmed/commentcorrection/17140466-12932091, http://linkedlifedata.com/resource/pubmed/commentcorrection/17140466-14640496, http://linkedlifedata.com/resource/pubmed/commentcorrection/17140466-14739024, http://linkedlifedata.com/resource/pubmed/commentcorrection/17140466-15275063, http://linkedlifedata.com/resource/pubmed/commentcorrection/17140466-15326348, http://linkedlifedata.com/resource/pubmed/commentcorrection/17140466-15462793, http://linkedlifedata.com/resource/pubmed/commentcorrection/17140466-15847846, http://linkedlifedata.com/resource/pubmed/commentcorrection/17140466-15917494, http://linkedlifedata.com/resource/pubmed/commentcorrection/17140466-16014861, http://linkedlifedata.com/resource/pubmed/commentcorrection/17140466-16172494, http://linkedlifedata.com/resource/pubmed/commentcorrection/17140466-16442537, http://linkedlifedata.com/resource/pubmed/commentcorrection/17140466-2180332, http://linkedlifedata.com/resource/pubmed/commentcorrection/17140466-2217664, http://linkedlifedata.com/resource/pubmed/commentcorrection/17140466-2469769, http://linkedlifedata.com/resource/pubmed/commentcorrection/17140466-2972535, http://linkedlifedata.com/resource/pubmed/commentcorrection/17140466-3079312, http://linkedlifedata.com/resource/pubmed/commentcorrection/17140466-3318021, http://linkedlifedata.com/resource/pubmed/commentcorrection/17140466-3899939, http://linkedlifedata.com/resource/pubmed/commentcorrection/17140466-6189787, http://linkedlifedata.com/resource/pubmed/commentcorrection/17140466-6392499, http://linkedlifedata.com/resource/pubmed/commentcorrection/17140466-7659017, http://linkedlifedata.com/resource/pubmed/commentcorrection/17140466-7909108, http://linkedlifedata.com/resource/pubmed/commentcorrection/17140466-8036244, http://linkedlifedata.com/resource/pubmed/commentcorrection/17140466-8069306, http://linkedlifedata.com/resource/pubmed/commentcorrection/17140466-8074247, http://linkedlifedata.com/resource/pubmed/commentcorrection/17140466-8103627, http://linkedlifedata.com/resource/pubmed/commentcorrection/17140466-8253160, http://linkedlifedata.com/resource/pubmed/commentcorrection/17140466-8264734, http://linkedlifedata.com/resource/pubmed/commentcorrection/17140466-8761562, http://linkedlifedata.com/resource/pubmed/commentcorrection/17140466-8812316, http://linkedlifedata.com/resource/pubmed/commentcorrection/17140466-9406786, http://linkedlifedata.com/resource/pubmed/commentcorrection/17140466-9449730, http://linkedlifedata.com/resource/pubmed/commentcorrection/17140466-9574911, http://linkedlifedata.com/resource/pubmed/commentcorrection/17140466-9623932, http://linkedlifedata.com/resource/pubmed/commentcorrection/17140466-9774600
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0031-1820
pubmed:author
pubmed:issnType
Print
pubmed:volume
134
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
637-50
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
More...