Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2006-11-24
pubmed:abstractText
Severe malaria is commonly misdiagnosed in Africa, leading to a failure to treat other life-threatening illnesses. In malaria-endemic areas, parasitemia does not ensure a diagnosis of severe malaria because parasitemia can be incidental to other concurrent disease. The detection of malarial retinopathy is a candidate diagnostic test for cerebral malaria. Malarial retinopathy consists of a set of retinal abnormalities that is unique to severe malaria and common in children with cerebral malaria. Its presence and severity are related to risk of death and length of coma in survivors. A large, prospective autopsy study of children dying with cerebral malaria in Malawi found that malarial retinopathy was better than any other clinical or laboratory feature in distinguishing malarial from non-malarial coma. However, visualization has to date relied on specialist examination techniques. Further studies are planned to evaluate the usefulness of funduscopy by general clinicians in a variety of settings across Africa. Studies of the retina and retinal blood vessels provide an unparalleled opportunity to visualize an infected microvasculature and its effect on neural tissue in vivo. This report reviews current knowledge of malarial retinopathy, including its use as a diagnostic test in the comatose child, and its value as a tool for research into the pathophysiology of cerebral malaria.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/17123967-10024950, http://linkedlifedata.com/resource/pubmed/commentcorrection/17123967-10232526, http://linkedlifedata.com/resource/pubmed/commentcorrection/17123967-10407208, http://linkedlifedata.com/resource/pubmed/commentcorrection/17123967-10717749, http://linkedlifedata.com/resource/pubmed/commentcorrection/17123967-10900105, http://linkedlifedata.com/resource/pubmed/commentcorrection/17123967-11103309, http://linkedlifedata.com/resource/pubmed/commentcorrection/17123967-11273135, http://linkedlifedata.com/resource/pubmed/commentcorrection/17123967-11816433, http://linkedlifedata.com/resource/pubmed/commentcorrection/17123967-11989526, http://linkedlifedata.com/resource/pubmed/commentcorrection/17123967-12184856, http://linkedlifedata.com/resource/pubmed/commentcorrection/17123967-12229865, http://linkedlifedata.com/resource/pubmed/commentcorrection/17123967-12229866, http://linkedlifedata.com/resource/pubmed/commentcorrection/17123967-12363065, http://linkedlifedata.com/resource/pubmed/commentcorrection/17123967-12702784, http://linkedlifedata.com/resource/pubmed/commentcorrection/17123967-12803862, http://linkedlifedata.com/resource/pubmed/commentcorrection/17123967-12848724, http://linkedlifedata.com/resource/pubmed/commentcorrection/17123967-14745442, http://linkedlifedata.com/resource/pubmed/commentcorrection/17123967-14977760, http://linkedlifedata.com/resource/pubmed/commentcorrection/17123967-15019349, http://linkedlifedata.com/resource/pubmed/commentcorrection/17123967-15177148, http://linkedlifedata.com/resource/pubmed/commentcorrection/17123967-15254565, http://linkedlifedata.com/resource/pubmed/commentcorrection/17123967-15302654, http://linkedlifedata.com/resource/pubmed/commentcorrection/17123967-15510945, http://linkedlifedata.com/resource/pubmed/commentcorrection/17123967-15542534, http://linkedlifedata.com/resource/pubmed/commentcorrection/17123967-15846481, http://linkedlifedata.com/resource/pubmed/commentcorrection/17123967-15871128, http://linkedlifedata.com/resource/pubmed/commentcorrection/17123967-16175479, http://linkedlifedata.com/resource/pubmed/commentcorrection/17123967-17488892, http://linkedlifedata.com/resource/pubmed/commentcorrection/17123967-2027172, http://linkedlifedata.com/resource/pubmed/commentcorrection/17123967-2053813, http://linkedlifedata.com/resource/pubmed/commentcorrection/17123967-6353955, http://linkedlifedata.com/resource/pubmed/commentcorrection/17123967-7723795, http://linkedlifedata.com/resource/pubmed/commentcorrection/17123967-8103627, http://linkedlifedata.com/resource/pubmed/commentcorrection/17123967-8252902, http://linkedlifedata.com/resource/pubmed/commentcorrection/17123967-8510897, http://linkedlifedata.com/resource/pubmed/commentcorrection/17123967-8761574, http://linkedlifedata.com/resource/pubmed/commentcorrection/17123967-9015508, http://linkedlifedata.com/resource/pubmed/commentcorrection/17123967-9258221, http://linkedlifedata.com/resource/pubmed/commentcorrection/17123967-9337004
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0002-9637
pubmed:author
pubmed:issnType
Print
pubmed:volume
75
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
790-7
pubmed:dateRevised
2011-2-17
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Malarial retinopathy: a newly established diagnostic sign in severe malaria.
pubmed:affiliation
Malawi-Liverpool-Wellcome Trust Clinical Research Programme, College of Medicine, Blantyre, Malawi. nbeare@btinternet.com
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural