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rdf:type |
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|
lifeskim:mentions |
|
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pubmed:issue |
4
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pubmed:dateCreated |
2006-11-22
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pubmed:abstractText |
We investigated the aqueous solubility of paclitaxel using 11 kinds of cyclodextrins (CDs) and the bioactivity of the paclitaxel-CD inclusion complex. 2,6-Dimethyl beta-cyclodextrin was the most effective and its solubility was 2.3 mM in a 0.1 M 2,6-dimethyl beta-cyclodextrin aqueous solution. The inclusion complex of paclitaxel and 2,6-dimethyl beta-cyclodextrin had a 1.23-fold polymerization activity as paclitaxel in a tubulin assay.
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1389-1723
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
102
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
369-71
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pubmed:meshHeading |
|
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pubmed:year |
2006
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pubmed:articleTitle |
Enhancement of water-solubility and bioactivity of paclitaxel using modified cyclodextrins.
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pubmed:affiliation |
Department of Life Science, Okayama University of Science, 1-1 Ridai-cho, Okayama 700-0005, Japan. hamada@das.ous.ac.jp
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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