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pubmed-article:17112808pubmed:abstractTextGrapefruit juice is an inhibitor of the cytochrome P450 (CYP) 3A4 enzyme and transporters such as P-glycoprotein and organic anion transporting polypeptides, leading to clinically important interactions. Our objective was to study the effect of grapefruit juice on the pharmacokinetics of nicotine, which is primarily metabolized by the CYP2A6 enzyme.lld:pubmed
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pubmed-article:17112808pubmed:articleTitleEffect of grapefruit juice on cytochrome P450 2A6 and nicotine renal clearance.lld:pubmed
pubmed-article:17112808pubmed:affiliationDivision of Clinical Pharmacology and Experimental Therapeutics, Medical Service, San Francisco General Hospital Medical Center, and Department of Medicine, University of California, San Francisco 94143-1220, USA.lld:pubmed
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