17112808

Source:http://linkedlifedata.com/resource/pubmed/id/17112808

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0010762, umls-concept:C0028040, umls-concept:C0232813, umls-concept:C0452456, umls-concept:C0699829, umls-concept:C1280500
pubmed:issue	5
pubmed:dateCreated	2006-11-20
pubmed:abstractText	Grapefruit juice is an inhibitor of the cytochrome P450 (CYP) 3A4 enzyme and transporters such as P-glycoprotein and organic anion transporting polypeptides, leading to clinically important interactions. Our objective was to study the effect of grapefruit juice on the pharmacokinetics of nicotine, which is primarily metabolized by the CYP2A6 enzyme.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/5-M01-RR-00083-41, http://linkedlifedata.com/resource/pubmed/grant/DA02277, http://linkedlifedata.com/resource/pubmed/grant/DA12393
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/0372741
pubmed:citationSubset	AIM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Aryl Hydrocarbon Hydroxylases, http://linkedlifedata.com/resource/pubmed/chemical/Cotinine, http://linkedlifedata.com/resource/pubmed/chemical/Deuterium, http://linkedlifedata.com/resource/pubmed/chemical/Ganglionic Stimulants, http://linkedlifedata.com/resource/pubmed/chemical/Glucuronides, http://linkedlifedata.com/resource/pubmed/chemical/Mixed Function Oxygenases, http://linkedlifedata.com/resource/pubmed/chemical/Nicotine, http://linkedlifedata.com/resource/pubmed/chemical/coumarin 7-hydroxylase, http://linkedlifedata.com/resource/pubmed/chemical/hydroxycotinine, http://linkedlifedata.com/resource/pubmed/chemical/norcotinine
pubmed:status	MEDLINE
pubmed:month	Nov
pubmed:issn	0009-9236
pubmed:author	pubmed-author:BenowitzNeal LNL, pubmed-author:HukkanenJanneJ, pubmed-author:JacobPeytonP3rd
pubmed:issnType	Print
pubmed:volume	80
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	522-30
pubmed:dateRevised	2007-12-3
pubmed:meshHeading	pubmed-meshheading:17112808-Administration, Oral, pubmed-meshheading:17112808-Adult, pubmed-meshheading:17112808-Area Under Curve, pubmed-meshheading:17112808-Aryl Hydrocarbon Hydroxylases, pubmed-meshheading:17112808-Beverages, pubmed-meshheading:17112808-Citrus paradisi, pubmed-meshheading:17112808-Cotinine, pubmed-meshheading:17112808-Deuterium, pubmed-meshheading:17112808-Female, pubmed-meshheading:17112808-Ganglionic Stimulants, pubmed-meshheading:17112808-Glucuronides, pubmed-meshheading:17112808-Half-Life, pubmed-meshheading:17112808-Humans, pubmed-meshheading:17112808-Kidney, pubmed-meshheading:17112808-Liver, pubmed-meshheading:17112808-Male, pubmed-meshheading:17112808-Metabolic Clearance Rate, pubmed-meshheading:17112808-Middle Aged, pubmed-meshheading:17112808-Mixed Function Oxygenases, pubmed-meshheading:17112808-Nicotine
pubmed:year	2006
pubmed:articleTitle	Effect of grapefruit juice on cytochrome P450 2A6 and nicotine renal clearance.
pubmed:affiliation	Division of Clinical Pharmacology and Experimental Therapeutics, Medical Service, San Francisco General Hospital Medical Center, and Department of Medicine, University of California, San Francisco 94143-1220, USA.
pubmed:publicationType	Journal Article, Clinical Trial, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural