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pubmed:abstractText |
Sepsis activates the coagulation system and frequently causes hypercoagulability, which is not detected by routine coagulation tests. A reliable method to evaluate hypercoagulability is thromboelastography (TEG), but this has not so far been used to investigate sepsis-induced hypercoagulability. Antithrombin (AT) in plasma of septic patients is decreased, and administration of AT may therefore reduce the acquired hypercoagulability. Not clear, however, is to what extent supraphysiologic plasma levels of AT decrease the acute hypercoagulability in septic patients. The present study investigates the coagulation profile of septic patients before and during four day high-dose AT therapy.
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pubmed:affiliation |
Department of Anesthesiology and General Intensive Care, Medical University of Vienna, Waehringer Gürtel 18-20, A-1090 Vienna, Austria. christopher.gonano@meduniwien.ac.at
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