Linked Life Data

1710522

Source:http://linkedlifedata.com/resource/pubmed/id/1710522

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1991-7-15
pubmed:abstractText
A number of recent advances have resulted in the definition of human pluripotent hemopoietic progenitors that can be considered candidates for stem cells. These cells may be CD34 positive and HLA-DR negative. They are capable of producing colonies composed of cells with blast-like morphology and re-establish long term bone marrow cultures when placed on irradiated stromal layers. These cells appear to interact at short range with stromal cells and become responsive to signals that initiate their proliferation and differentiation. These signals can be provided by interleukins produced by various auxiliary hemopoietic cell populations and may act over long distances. In addition, these interleukins may be aberrantly produced by certain malignant hemopoietic cells. This may result in paramoplastic auto- or paracrine growth promotion of the underlying malignancy and occasionally in the development of paraneoplastic syndromes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0268-3369
pubmed:author
pubmed:issnType
Print
pubmed:volume
7 Suppl 1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
18-22
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Human hemopoietic progenitors and their signals.
pubmed:affiliation
Ontario Cancer Institute, Department of Medicine, University of Toronto, Canada.
pubmed:publicationType
Journal Article, Review