Linked Life Data

17101294

Source:http://linkedlifedata.com/resource/pubmed/id/17101294

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2007-1-15
pubmed:abstractText
Dendritic cells (DCs) are the single most central player in all immune responses. To assess whether DC alterations may contribute to the immune dysregulation that affects the elderly, we investigated the effects of ageing on DCs. We analyzed the number, phenotype and function of peripheral blood DCs from 70 healthy subjects aged 20-92 years by using flow cytometric methods that allow cell characterization directly in whole blood samples. We demonstrated that the number of myeloid DCs progressively declines with age. This finding was accompanied by a decrease of CD34+ precursors and increase of circulating monocytes, suggesting that the entire differentiation process of antigen presenting cells is partially dysregulated in the elderly. DCs from aged individuals also appeared to have a more mature phenotype and impaired ability to produce IL-12 upon stimulation. These results may help to clarify the contribution of innate immunity to the development of immunosenescence.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1521-6616
pubmed:author
pubmed:issnType
Print
pubmed:volume
122
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
220-8
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Peripheral blood dendritic cells and monocytes are differently regulated in the elderly.
pubmed:affiliation
Dipartimento di Scienze e Tecnologie Biomediche, Laboratorio di Immunologia, Università degli Studi di Milano, Milano, Italy. silvia.dellabella@unimi.it <silvia.dellabella@unimi.it>
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't