Source:http://linkedlifedata.com/resource/pubmed/id/17100737
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
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pubmed:dateCreated |
2006-11-14
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pubmed:abstractText |
Ultraviolet (UV) radiation damages the cellular DNA of skin cells. In response, wild-type p53 protein accumulates in irradiated cells and the stabilized and transactivated protein can then induce genes involved in cell cycle arrest in G1, or in the initiation of apoptosis. Selenium protects cells from UVB-induced cell death and apoptosis by mechanisms which are unclear, although recent reports suggest that selenium protects against UV-induced cell damage by inducing DNA repair enzymes and transactivating p53.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0905-4383
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
22
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
297-303
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pubmed:meshHeading |
pubmed-meshheading:17100737-Apoptosis,
pubmed-meshheading:17100737-Cell Division,
pubmed-meshheading:17100737-Cell Line, Tumor,
pubmed-meshheading:17100737-Dose-Response Relationship, Drug,
pubmed-meshheading:17100737-Dose-Response Relationship, Radiation,
pubmed-meshheading:17100737-Humans,
pubmed-meshheading:17100737-Radiation-Protective Agents,
pubmed-meshheading:17100737-Selenomethionine,
pubmed-meshheading:17100737-Skin,
pubmed-meshheading:17100737-Tumor Suppressor Protein p53,
pubmed-meshheading:17100737-Ultraviolet Rays
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pubmed:year |
2006
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pubmed:articleTitle |
Selenomethionine inhibits ultraviolet radiation-induced p53 transactivation.
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pubmed:affiliation |
Photobiology Unit, Ninewells Hospital, University of Dundee, Dundee, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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