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pubmed-article:17092836pubmed:abstractTextA series of novel polymeric nanogels with core-shell morphology was developed. Block ionomer complexes of comb-graft poly(ethylene oxide)-b-poly(polypropylene oxide)-b-poly(ethylene oxide)-g-poly(acrylic acid) copolymers (Pluronic-PAA) and divalent metal cations were utilized as micellar templates for the synthesis of nanogels with sizes ranging from 100 to 200 nm in diameter. The Pluronic-PAA nanogels were confirmed to possess ionic cross-linked PAA cores and flexible hydrophilic shells from the Pluronic copolymer chains. The ionic character of the core provided for pH-dependent swelling/collapse behavior of the nanogels. These prepared nanogels are expected to be of utility as carriers for charged therapeutic or diagnostic agents.lld:pubmed
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pubmed-article:17092836pubmed:dateRevised2010-11-18lld:pubmed
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pubmed-article:17092836pubmed:articleTitleTemplate-assisted synthesis of nanogels from Pluronic-modified poly(acrylic acid).lld:pubmed
pubmed-article:17092836pubmed:affiliationDepartment of Pharmaceutical Sciences and Center for Drug Delivery and Nanomedicine, College of Pharmacy, University of Nebraska Medical Center, 985830 Nebraska Medical Center, Omaha, NE 68198-5830, USA. tbronich@unmc.edulld:pubmed
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